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Open AccessArticle

Allomyrina Dichotoma Larvae Regulate Food Intake and Body Weight in High Fat Diet-Induced Obese Mice Through mTOR and Mapk Signaling Pathways

1
Department of Anatomy, Graduate School of Dongguk University College of Medicine, Gyeongju 38066, Korea
2
Department of Agricultural Biology, National Academy of Agricultural Science, RDA, Wanju-gun 55365, Korea
3
Department of Biotechnology, Catholic University of Daegu, Daegu 38430, Korea
4
Department of Biochemistry, Dongguk University College of Medicine, Gyeongju 38066, Korea
*
Authors to whom correspondence should be addressed.
Nutrients 2016, 8(2), 100; https://doi.org/10.3390/nu8020100
Received: 22 December 2015 / Revised: 2 February 2016 / Accepted: 4 February 2016 / Published: 18 February 2016
(This article belongs to the Special Issue Diet and Metabolic Dysfunction)
Recent evidence has suggested that the Korean horn beetle (Allomyrina dichotoma) has anti-hepatofibrotic, anti-neoplastic, and antibiotic effects and is recognized as a traditional medicine. In our previous works, Allomyrina dichotoma larvae (ADL) inhibited differentiation of adipocytes both in vitro and in vivo. However, the anorexigenic and endoplasmic reticulum(ER) stress-reducing effects of ADL in obesity has not been examined. In this study, we investigated the anorexigenic and ER stress-reducing effects of ADL in the hypothalamus of diet-induced obese (DIO) mice. Intracerebroventricular (ICV) administration of ethanol extract of ADL (ADE) suggested that an antagonizing effect on ghrelin-induced feeding behavior through the mTOR and MAPK signaling pathways. Especially, ADE resulted in strong reduction of ER stress both in vitro and in vivo. These findings strongly suggest that ADE and its constituent bioactive compounds are available and valuable to use for treatment of various diseases driven by prolonged ER stress. View Full-Text
Keywords: Allomyrina dichotoma larvae; diet-induced obesity; ER stress; hypothalamus; appetite Allomyrina dichotoma larvae; diet-induced obesity; ER stress; hypothalamus; appetite
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Kim, J.; Yun, E.-Y.; Park, S.-W.; Goo, T.-W.; Seo, M. Allomyrina Dichotoma Larvae Regulate Food Intake and Body Weight in High Fat Diet-Induced Obese Mice Through mTOR and Mapk Signaling Pathways. Nutrients 2016, 8, 100.

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