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Open AccessArticle

Low Maternal Vitamin B12 Status Is Associated with Lower Cord Blood HDL Cholesterol in White Caucasians Living in the UK

Warwick Medical School, University of Warwick, Coventry CV2 2DX, UK
Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford OX3 9DU, UK
Department of Pathology, Heartlands Hospital, Birmingham B9 5SS, UK
Academic department of Diabetes and Metabolism, George Eliot Hospital, Nuneaton CV10 7DJ, UK
Diabetes Research Centre, KEM Hospital, Pune 411011, India
WISDEM Centre, University Hospital Coventry and Warwickshire, Coventry CV2 2DX, UK
Authors to whom correspondence should be addressed.
Nutrients 2015, 7(4), 2401-2414;
Received: 29 January 2015 / Revised: 19 March 2015 / Accepted: 24 March 2015 / Published: 2 April 2015
(This article belongs to the Special Issue Nutrition in Pregnancy)
Background and Aims: Studies in South Asian population show that low maternal vitamin B12 associates with insulin resistance and small for gestational age in the offspring. Low vitamin B12 status is attributed to vegetarianism in these populations. It is not known whether low B12 status is associated with metabolic risk of the offspring in whites, where the childhood metabolic disorders are increasing rapidly. Here, we studied whether maternal B12 levels associate with metabolic risk of the offspring at birth. Methods: This is a cross-sectional study of 91 mother-infant pairs (n = 182), of white Caucasian origin living in the UK. Blood samples were collected from white pregnant women at delivery and their newborns (cord blood). Serum vitamin B12, folate, homocysteine as well as the relevant metabolic risk factors were measured. Results: The prevalence of low serum vitamin B12 (<191 ng/L) and folate (<4.6 μg/L) were 40% and 11%, respectively. Maternal B12 was inversely associated with offspring’s Homeostasis Model Assessment 2-Insulin Resistance (HOMA-IR), triglycerides, homocysteine and positively with HDL-cholesterol after adjusting for age and BMI. In regression analysis, after adjusting for likely confounders, maternal B12 is independently associated with neonatal HDL-cholesterol and homocysteine but not triglycerides or HOMA-IR. Conclusions: Our study shows that low B12 status is common in white women and is independently associated with adverse cord blood cholesterol. View Full-Text
Keywords: vitamin B12; maternal; offspring; metabolic risk; lipids vitamin B12; maternal; offspring; metabolic risk; lipids
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Adaikalakoteswari, A.; Vatish, M.; Lawson, A.; Wood, C.; Sivakumar, K.; McTernan, P.G.; Webster, C.; Anderson, N.; Yajnik, C.S.; Tripathi, G.; Saravanan, P. Low Maternal Vitamin B12 Status Is Associated with Lower Cord Blood HDL Cholesterol in White Caucasians Living in the UK. Nutrients 2015, 7, 2401-2414.

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