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Article

Dietary Advanced Glycation End Products (AGEs) and Urinary Fluorescent AGEs in Children and Adolescents: Findings from the Italian I.Family Project

1
Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
2
Department of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, Italy
3
Leibniz Institute for Prevention Research and Epidemiology—BIPS, 28359 Bremen, Germany
4
Epidemiology and Prevention Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(12), 1831; https://doi.org/10.3390/nu16121831
Submission received: 2 May 2024 / Revised: 29 May 2024 / Accepted: 10 June 2024 / Published: 11 June 2024

Abstract

Advanced glycation end products (AGEs) have been implicated in chronic diseases in adults, but their role in paediatric populations remains uncertain. This study, conducted on the Italian sample of the I.Family project, aimed to investigate the relationship between dietary and urinary fluorescent AGEs in children and adolescents. The secondary objective was to investigate the sources of dietary AGEs (dAGEs) and their association with dietary composition and anthropometric parameters. Dietary data were collected from 1048 participants via 24 h dietary recall in 2013/2014 to estimate dAGEs intake, while urinary fluorescent AGE levels were measured in 544 individuals. Participants were stratified based on dAGEs intake and compared with respect to urinary fluorescent AGE levels, anthropometric measurements, and dietary intake. The results showed no significant correlation between dietary and urinary fluorescent AGE levels, nor between dAGEs and anthropometric parameters. Notably, higher dAGEs were associated with a diet richer in protein (especially from meat sources) and fat and lower in carbohydrates. In addition, the consumption of ultra-processed foods was lower in participants with a higher DAGE intake. This study highlights the lack of a clear association between dietary and urinary fluorescent AGEs in children, but suggests a distinctive dietary pattern associated with increased dAGEs intake. Further investigation is warranted to elucidate the potential health implications of dAGEs in paediatric populations.
Keywords: advanced glycation end products (AGEs); urinary AGEs; diet; children; I.Family project; ultra-processed foods (UPF); population study advanced glycation end products (AGEs); urinary AGEs; diet; children; I.Family project; ultra-processed foods (UPF); population study

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MDPI and ACS Style

Dello Russo, M.; Sirangelo, I.; Lauria, F.; Formisano, A.; Iannuzzi, C.; Hebestreit, A.; Pala, V.; Siani, A.; Russo, P. Dietary Advanced Glycation End Products (AGEs) and Urinary Fluorescent AGEs in Children and Adolescents: Findings from the Italian I.Family Project. Nutrients 2024, 16, 1831. https://doi.org/10.3390/nu16121831

AMA Style

Dello Russo M, Sirangelo I, Lauria F, Formisano A, Iannuzzi C, Hebestreit A, Pala V, Siani A, Russo P. Dietary Advanced Glycation End Products (AGEs) and Urinary Fluorescent AGEs in Children and Adolescents: Findings from the Italian I.Family Project. Nutrients. 2024; 16(12):1831. https://doi.org/10.3390/nu16121831

Chicago/Turabian Style

Dello Russo, Marika, Ivana Sirangelo, Fabio Lauria, Annarita Formisano, Clara Iannuzzi, Antje Hebestreit, Valeria Pala, Alfonso Siani, and Paola Russo. 2024. "Dietary Advanced Glycation End Products (AGEs) and Urinary Fluorescent AGEs in Children and Adolescents: Findings from the Italian I.Family Project" Nutrients 16, no. 12: 1831. https://doi.org/10.3390/nu16121831

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