Copper and Zinc Content in Infant Milk Formulae Available on the Polish Market and Contribution to Dietary Intake
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Sample Preparation and Determination of Elements
2.3. Data Analyzes
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Type of Formulae for Infants | Number of Samples (Number of Different Formulae) * | Cu mg/100 g Powder | Zn mg/100 g Powder | Cu/Zn |
---|---|---|---|---|
Median (1st–3rd Quartile) <Min–Max> | ||||
Total formulae for infants (0–12 months) | 103 (90) | 0.34 (0.29–0.37) | 4.18 (3.83–5.09) | 1:13 (1:11–1:15) |
<0.20–1.00> | <3.22–10.10> | <1:8–1:25> | ||
Infant formulae (0–6 months) | 36 (30) | 0.33 (0.29–0.36) | 4.00 (3.64–4.29) | 1:12 (1:11–1:14) |
<0.23–0.43> | <3.31–6.11> | <1:9–1:19> | ||
Infant formulae manufactured from cows’ milk proteins | 25 (21) | 0.34 (0.30–0.36) | 3.89 (3.64–4.22) | 1:12 (1:11–1:14) |
<0.23–0.43> | <3.31–6.11> | <1:9–1:19> | ||
Infant formulae manufactured from goats’ milk proteins | 4 (3) | 0.34 (0.27–0.39) | 4.02 (3.58–4.90) | 1:12 (1:12–1:13) |
<0.27–0.39> | <3.58–4.90> | <1:12–1:13> | ||
Infant formulae manufactured from protein hydrolysates | 7 (6) | 0.33 (0.29–0.34) | 4.13 (3.99–4.37) | 1:13 (1:12–1:14) |
<0.28–0.36> | <3.36–4.72> | <1:10–1:15> | ||
Follow–on formulae (7–12 months) | 31 (29) | 0.34 (0.28–0.36) | 4.13 (3.83–4.59) | 1:13 (1:11–1:15) |
<0.22–0.41> | <3.22–5.74> | <1:8–1:24> | ||
Follow–on formulae manufactured from cows’ milk proteins | 23 (21) | 0.34 (0.29–0.36) | 4.12 (3.83–4.32) | 1:12 (1:11–1:15) |
<0.22–0.40> | <3.22–5.44> | <1:8–1:22> | ||
Follow–on formulae manufactured from goats’ milk proteins | 4 | 0.36 (0.31–0.39) | 4.64 (4.46–4.73) | 1:13 (1:12–1:15) |
<0.26–0.41> | <4.34–4.77> | <1:11–1:18> | ||
Follow–on formulae manufactured from protein hydrolysates | 4 | 0.27 (0.25–0.30) | 3.88 (0.77–4.84) | 1:14 (1:13–1:19) |
<0.24–0.32> | <3.70–5.74> | <1:12–1:24> | ||
Formula for special medical purposes intended for infants | 36 (31) | 0.36 (0.32–0.42) | 5.16 (3.89–5.72) | 1:13 (1:12–1:16) |
<0.20–1.00> | <3.23–10.10> | <1:8–1:25> | ||
Formula for special medical purposes intended for infants from birth | 31 (26) | 0.38 (0.32–0.41) | 4.90 (3.80–5.20) | 1:13 (1:11–1:15) |
<0.27–0.95> | <3.50–8.60> | <1:8–1:25> | ||
Formula for special medical purposes intended for infants from 7 months | 5 | 0.36 (0.28–0.37) | 4.70 (3.50–4.90) | 1:15 (1:12–1:16) |
<0.28–0.37> | <3.40–5.30> | <1:12–1:16> | ||
Extensively hydrolyzed formulae | 7 (6) | 0.35 (0.29–0.36) | 4.12 (3.87–5.37) | 1:13 (1:11–1:16) |
<0.28–0.46> | <3.61–5.64> | <1:9–1:16> | ||
Amino acid–based formulae | 4 (2) | 0.42 (0.40–0.45) | 5.21 (5.16–5.25) | 1:12 (1:12–1:13) |
<0.40–0.45> | <5.16–5.25> | <1:12–1:13> | ||
Anti–reflux formulae | 5 | 0.34 (0.33–0.35) | 5.04 (4.96–5.16) | 1:15 (1:14–1:16) |
<0.20–0.40> | <4.84–5.44> | <1:12–1:25> | ||
Comfort–formulae | 7 | 0.36 (0.27–0.42) | 4.86 (3.74–5.37) | 1:13 (1:12–1:14) |
<0.26–0.43> | <3.23–5.72> | <1:9–1:17> | ||
Lactose–free formulae | 2 | 0.40 <0.36–0.45> | 4.92 <3.88–5.95> | 1:12 <1:11–1:13> |
Preterm formulae | 4 (3) | 0.44 (0.42–0.69) | 6.63 (5.79–6.80) | 1:15 (1:8–1:16) |
<0.42–0.69> | <5.79–6.80> | <1:8–1:16> | ||
Soya–based formula for infants | 1 | 0.30 | 5.75 | 1:19 |
Medium chain triglycerides formulae | 3 (2) | 0.30 | 3.94 | 1:13 |
<0.28–0.32> | <3.69–4.18> | <1:13–1:13> | ||
Phenylalanine–free formulae (complete) | 3 | 0.37 | 6.56 | 1:11 |
<0.35–1.00> | <3.72–10.10> | <1:10–1:18> |
Type of Formula for Infants | Number of Samples (Number of Different Formulae) * | Cu mg/100 Kcal Formula | Zn mg/100 Kcal Formula |
---|---|---|---|
Median (1st–3rd Quartile) <Min–Max> | |||
Total formulae for infants (0–12 months) | 103 (90) | 0.069 (0.061–0.078) | 0.86 (0.79–1.04) |
<0.040–0.198> | <0.66–2.01> | ||
Infant formulae (0–6 months) | 36 (30) | 0.067 (0.059–0.072) | 0.81 (0.73–0.92) |
<0.044–0.086> | <0.66–1.34> | ||
Infant formulae manufactured from cows’ milk proteins | 25 (21) | 0.068 (0.059–0.072) | 0.79 (0.72–0.99) |
<0.044–0.086> | <0.66–1.34> | ||
Infant formulae manufactured from goats’ milk proteins | 4 (3) | 0.067 (0.055–0.077) | 0.80 (0.73–0.96) |
<0.055–0.077> | <0.73–0.96> | ||
Infant formulae manufactured from protein hydrolysates | 7 (6) | 0.066 (0.061–0.070) | 0.85 (0.84–0.89) |
<0.057–0.072> | <0.66–0.92> | ||
Follow–on formulae (7–12 months) | 31 (29) | 0.067 (0.059–0.080) | 0.87 (0.82–0.97) |
<0.045–0.086> | <0.70–1.17> | ||
Follow–on formulae manufactured from cows’ milk proteins | 23 (21) | 0.068 (0.062–0.081) | 0.84 (0.82–1.00) |
<0.045–0.086> | <0.70–1.16> | ||
Follow–on formulae manufactured from goats’ milk proteins | 4 | 0.072 (0.061–0.077) | 0.92 (0.89–0.95) |
<0.053–0.080> | <0.87–0.97> | ||
Follow–on formulae manufactured from protein hydrolysates | 4 | 0.059 (0.053–0.063) | 0.85 (0.82–1.01) |
<0.050–0.064> | <0.80–1.17> | ||
Formula for special medical purposes intended for infants | 36 (31) | 0.071 (0.065–0.083) | 1.04 (0.81–1.14) |
<0.040–0.198> | <0.70–2.01> | ||
Formula for special medical purposes intended for infants from birth | 31 (26) | 0.074 (0.065–0.085) | 1.03 (0.82–1.14) |
<0.040–0.198> | <0.71–2.01> | ||
Formula for special medical purposes intended for infants from 7 months | 5 | 0.071 (0.062–0.073) | 1.05 (0.76–1.14) |
<0.056–0.078> | <0.70–1.22> | ||
Extensively hydrolyzed formulae | 7 (6) | 0.071 (0.062–0.078) | 0.82 (0.77–1.14) |
<0.057–0.090> | <0.76–1.22> | ||
Amino acid–based formulae | 4 (2) | 0.086 (0.083–0.089) | 1.05 (1.04–1.06) |
<0.083–0.089> | <1.04–1.06> | ||
Anti–reflux formulae | 5 | 0.070 (0.065–0.071) | 1.02 (1.01–1.05) |
<0.040–0.080> | <0.99–1.06> | ||
Comfort–formulae | 7 | 0.070 (0.057–0.081) | 0.95 (0.78–1.11) |
<0.056–0.090> | <0.70–1.14> | ||
Lactose–free formulae | 2 | 0.078 <0.070–0.085> | 0.95 <0.77–1.13> |
Preterm formulae | 4 (3) | 0.091 (0.083–0.138) | 1.35 (1.15–1.35) |
<0.083–0.138> | <1.15–1.35> | ||
Soya–based formula for infants | 1 | 0.060 | 1.16 |
Medium chain triglycerides formulae | 3 (2) | 0.064 | 0.83 |
<0.063–0.065> | <0.82–0.85> | ||
Phenylalanine–free formulae (complete) | 3 | 0.080 | 1.41 |
<0.067–0.198> | <0.71–2.01> |
Type of Formula | Cu (mg) | Zn (mg) | ||
---|---|---|---|---|
Per 100 Kcal Formula | Per 100 Kcal Formula | |||
Minimum | Maximum | Minimum | Maximum | |
Infant formulae | 0.035 | 0.1 | 0.5 | 1.5 |
Follow-on formulae | 0.035 | 0.1 | 0.5 | 1.5 |
Formulae for special medical purposes for infants | 0.060 | 0.12 | 0.5 | 2.4 |
Type of Formulae for Infants | Number of Samples (Number of Different Formulae) * | 0 to <1 Month | 1 to <2 Months | 2 to <3 Months | 3 to <4 Months | 4 to <5 Months | 5 to <6 Months |
---|---|---|---|---|---|---|---|
Median (1st–3rd Quartile) <Min–Max> | |||||||
Total formulae for infants (0–12 months) | 103 (90) | ||||||
Cu | 0.24 (0.21–0.27) | 0.33 (0.29–0.37) | 0.35 (0.31–0.39) | 0.33 (0.29–0.37) | 0.36 (0.32–0.41) | 0.39 (0.34–0.44) | |
<0.14–0.68> | <0.19–0.95> | <0.20–0.99> | <0.19–0.95> | <0.21–1.04> | <0.23–1.11> | ||
Zn | 2.95 (2.73–3.59) | 4.09 (3.79–4.97) | 4.31 (3.99–5.24) | 4.11 (3.81–5.00) | 4.54 (4.17–5.48) | 4.82 (4.46–5.85) | |
<2.27–6.90> | <3.15–9.57> | <3.31–10.07> | <3.16–9.61> | <3.47–10.53> | <3.70–11.25> | ||
Infant formulae (0–6 months) | 36 (30) | ||||||
Cu | 0.23 (0.20–0.25) | 0.32 (0.28–0.34) | 0.34 (0.30–0.36) | 0.32 (0.28–0.34) | 0.35 (0.31–0.38) | 0.38 (0.33–0.40) | |
<0.15–0.29> | <0.21–0.41> | <0.22–0.43> | <0.21–0.41> | <0.23–0.45> | <0.25–0.48> | ||
Zn | 2.80 (2.52–3.18) | 3.88 (3.49–4.40) | 4.08 (3.67–4.64) | 3.89 (3.51–4.42) | 4.27 (3.84–4.85) | 4.56 (4.11–5.18) | |
<2.27–4.62> | <3.15–6.41> | <3.31–6.74> | <3.16–6.43> | <3.47–7.05> | <3.70–7.53> | ||
Infant formulae manufactured from cows’ milk proteins | 25 (21) | ||||||
Cu | 0.23 (0.20–0.25) | 0.32 (0.28–0.34) | 0.34 (0.30–0.36) | 0.32 (0.28–0.34) | 0.35 (0.31–0.38) | 0.38 (0.33–0.40) | |
<0.15–0.29> | <0.21–0.41> | <0.22–0.43> | <0.21–0.41> | <0.23–0.45> | <0.25–0.48> | ||
Zn | 2.73 (2.48–3.39) | 3.79 (3.45–4.70) | 3.99 (3.63–4.95) | 3.81 (3.46–4.72) | 4.17 (3.79–5.17) | 4.46 (4.05–5.53) | |
<2.27–4.62> | <3.15–6.41> | <3.31–6.74> | <3.16–6.43> | <3.47–7.05> | <3.70–7.53> | ||
Infant formulae manufactured from goats’ milk proteins | 4 (3) | ||||||
Cu | 0.23 (0.19–0.26) | 0.32 (0.260.37) | 0.34 (0.27–0.39) | 0.32 (0.26–0.37) | 0.35 (0.29–0.40) | 0.38 (0.31–0.43) | |
<0.19–0.26> | <0.26–0.37> | <0.27–0.39> | <0.26–0.37> | <0.29–0.40> | <0.31–0.43> | ||
Zn | 2.77 (2.53–3.30) | 3.84 (3.49–4.57) | 4.04 (3.67–4.81) | 3.85 (3.51–4.59) | 4.22 (3.84–5.03) | 4.51 (4.11–5.38) | |
<2.52–3.30> | <3.49–4.57> | <3.67–4.81> | <3.51–4.59> | <3.84–5.03> | <4.11–5.38> | ||
Infant formulae manufactured from protein hydrolysates | 7 (6) | ||||||
Cu | 0.23 (0.21–0.24) | 0.32 (0.29–0.33) | 0.33 (0.30–0.35) | 0.32 (0.29–0.34) | 0.35 (0.32–0.37) | 0.37 (0.34–0.39) | |
<0.20–0.25> | <0.27–0.34> | <0.29–0.36> | <0.28–0.34> | <0.30–0.38> | <0.32–0.40> | ||
Zn | 2.93 (2.87–3.05) | 4.07 (3.98–4.23) | 4.28 (4.19–4.45) | 4.08 (4.00–4.25) | 4.47 (4.38–4.66) | 4.78 (4.69–4.97) | |
<2.28–3.18> | <3.16–4.40> | <3.32–4.64> | <3.17–4.42> | <3.47–4.85> | <3.71–5.18> | ||
Formula for special medical purposes intended for infants (from birth) | 31 (26) | ||||||
Cu | 0.25 (0.22–0.29) | 0.35 (0.31–0.40) | 0.37 (0.33–0.43) | 0.35 (0.31–0.41) | 0.39 (0.34–0.44) | 0.42 (0.370.48) | |
<0.14–0.68> | <0.19–0.95> | <0.20–0.99> | <0.19–0.95> | <0.21–1.04> | <0.23–1.11> | ||
Zn | 3.55 (2.81–3.93) | 4.92 (3.89–5.45) | 5.18 (4.10–5.74) | 4.94 (3.91–5.47) | 5.42 (4.29–6.00) | 5.79 (4.58–6.41) | |
<2.45–6.90> | <3.39–9.57> | <3.57–10.07> | <3.40–9.61> | <3.73–10.53> | <3.99–11.25> | ||
Extensively hydrolyzed formulae | 3 | ||||||
Cu | 0.24 | 0.33 | 0.35 | 0.33 | 0.36 | 0.39 | |
<0.20–0.31> | <0.27–0.43> | <0.29–0.45> | <0.27–0.43> | <0.30–0.47> | <0.32–0.51> | ||
Zn | 2.80 | 3.88 | 4.08 | 3.89 | 4.27 | 4.56 | |
<2.65–2.87> | <3.67–3.98> | <3.86–4.18> | <3.68–3.99> | <4.04–4.38> | <4.31–4.68> | ||
Amino acid–based formulae | 4 (2) | ||||||
Cu | 0.30 (0.29–0.30) | 0.41 (0.40–0.42) | 0.43 (0.42–0.44) | 0.41 (0.40–0.42) | 0.45 (0.44–0.47) | 0.48 (0.47–0.50) | |
<0.29–0.30> | <0.40–0.42> | <0.42–0.44> | <0.40–0.42> | <0.44–0.47> | <0.47–0.50> | ||
Zn | 3.62 (3.59–3.65) | 5.02 (4.97–5.07) | 5.28 (5.24–5.33) | 5.04 (5.00–5.09) | 5.53 (5.48–5.58) | 5.91 (5.85–5.96) | |
<3.59–3.65> | <4.97–5.07> | <5.24–5.33> | <5.00–. 5.09> | <5.48–5.58> | <5.85–5.96> | ||
Anti–reflux formulae | 4 | ||||||
Cu | 0.23 (0.18–0.26) | 0.32 (0.25–0.36) | 0.34 (0.27–0.38) | 0.33 (0.25–0.36) | 0.36 (0.28–0.40) | 0.38 (0.30–0.42) | |
<0.14–0.28> | <0.19–0.38> | <0.20–040> | <0.19–0.38> | <0.21–0.42> | <0.23–0.45> | ||
Zn | 3.50 (3.41–3.66) | 4.85 (4.78–4.98) | 5.11 (5.03–5.24) | 4.87 (4.80–5.00) | 5.34 (5.26–5.48) | 5.71 (5.62–5.85) | |
<3.41–3.66> | <4.73–5.07> | <4.98–5.34> | <4.75–5.09> | <5.21–5.58> | <5.57–5.97> | ||
Comfort–formulae | 6 | ||||||
Cu | 0.25 (0.23–0.28) | 0.35 (0.32–0.39) | 0.37 (0.34–0.41) | 0.35 (0.33–0.39) | 0.39 (0.36–0.43) | 0.41 (0.38–0.46) | |
<0.20–0.31> | <0.27–0.43> | <0.29–0.45> | <0.27–0.43> | <0.30–0.47> | <0.32–0.50> | ||
Zn | 3.42 (2.80–3.82) | 4.74 (3.88–5.30) | 4.99 (4.08–5.58) | 4.76 (3.89–5.32) | 5.22 (4.27–5.83) | 5.57 (4.56–6.23) | |
<2.69–3.93> | <3.73–5.45> | <3.92–5.74> | <3.74–5.47> | <4.10–6.00> | <4.38–6.41> | ||
Lactose–free formulae | 2 | ||||||
Cu | 0.27 <0.24–0.29> | 0.37 <0.34–0.40> | 0.39 <0.35–0.43> | 0.37 <0.34–0.41> | 0.41 <0.37–0.44> | 0.44 <0.39–0.48> | |
Zn | 3.26 <2.6–3.88> | 4.52 <3.65–5.38> | 4.75 <3.84–5.67> | 4.54 <3.66–5.41> | 4.97 <4.02–5.93> | 5.31 <4.29–6.33> | |
Preterm formulae | 4 (3) | ||||||
Cu | 0.31 (0.29–0.47) | 0.43 (0.40–0.66) | 0.46 (0.42–0.69) | 0.43 (0.40–0.66) | 0.48 (0.44–0.72) | 0.51 (0.47–0.77) | |
<0.29–0.47> | <0.40–0.66> | <0.42–0.69> | <0.40–0.66> | <0.44–0.72> | <0.47–0.77> | ||
Zn | 4.65 (3.96–4.65) | 6.45 (5.49–6.45) | 6.78 (5.77–6.79) | 6.47 (5.51–6.48) | 7.09 (6.04–7.10) | 7.58 (6.45–7.59) | |
<3.96–4.65> | <5.49–6.45> | <5.77–6.79> | <5.51–6.48> | <6.04–7.10> | <6.45–7.59> | ||
Soya–based formula for infants | 1 | ||||||
Cu | 0.21 | 0.28 | 0.30 | 0.29 | 0.31 | 0.33 | |
Zn | 3.99 | 5.53 | 5.82 | 5.55 | 6.09 | 6.50 | |
Medium chain triglycerides formulae | 3 (2) | ||||||
Cu | 0.22 | 0.31 | 0.32 | 0.31) | 0.34 | 0.36 | |
<0.22–0.22> | <0.30–0.31> | <0.32–0.33> | <0.30–0.31> | <0.33–0.34> | <0.35–0.36> | ||
Zn | 2.86 | 3.97 | 4.17 | 3.98 | 4.36 | 4.66 | |
<2.81–2.91> | <3.89–4.04> | <4.10–4.25> | <3.91–4.05> | <4.29–4.44> | <4.58–4.75> | ||
Phenylalanine–free formulae (complete) | 3 | ||||||
Cu | 0.27 | 0.38 | 0.40 | 0.38 | 0.42 | 0.45 | |
<0.23–0.68> | <0.32–0.95> | <0.34–0.99> | <0.32–0.95> | <0.35–1.04> | <0.38–1.11> | ||
Zn | 4.83 | 6.70 | 7.05 | 6.73 | 7.38 | 7.88 | |
<2.45–6.90> | <3.39–9.57> | <3.57–10.07> | <3.40–9.61> | <3.73–10.53> | <3.99–11.25> |
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Dobrzyńska, M.; Drzymała-Czyż, S.; Jakubowski, K.; Kurek, S.; Walkowiak, J.; Przysławski, J. Copper and Zinc Content in Infant Milk Formulae Available on the Polish Market and Contribution to Dietary Intake. Nutrients 2021, 13, 2542. https://doi.org/10.3390/nu13082542
Dobrzyńska M, Drzymała-Czyż S, Jakubowski K, Kurek S, Walkowiak J, Przysławski J. Copper and Zinc Content in Infant Milk Formulae Available on the Polish Market and Contribution to Dietary Intake. Nutrients. 2021; 13(8):2542. https://doi.org/10.3390/nu13082542
Chicago/Turabian StyleDobrzyńska, Małgorzata, Sławomira Drzymała-Czyż, Karol Jakubowski, Szymon Kurek, Jarosław Walkowiak, and Juliusz Przysławski. 2021. "Copper and Zinc Content in Infant Milk Formulae Available on the Polish Market and Contribution to Dietary Intake" Nutrients 13, no. 8: 2542. https://doi.org/10.3390/nu13082542
APA StyleDobrzyńska, M., Drzymała-Czyż, S., Jakubowski, K., Kurek, S., Walkowiak, J., & Przysławski, J. (2021). Copper and Zinc Content in Infant Milk Formulae Available on the Polish Market and Contribution to Dietary Intake. Nutrients, 13(8), 2542. https://doi.org/10.3390/nu13082542