Next Article in Journal
Lifetime Weight Course as a Phenotypic Marker of Severity and Therapeutic Response in Patients with Eating Disorders
Previous Article in Journal
Higher Dietary Inflammation in Patients with Schizophrenia: A Case-Control Study in Korea
Article

Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study

1
Eurecat, Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut, 43204 Reus, Spain
2
Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC-Salut), Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain
3
Fundación para el Fomento de la Investigación Sanitaria y Biomédica, 46020 Valencia, Spain
4
CIBER en Epidemiología y Salud Pública, 28029 Madrid, Spain
5
Eurecat, Centre Tecnològic de Catalunya, Biotechnology Area, 43204 Reus, Spain
6
XaRTA-TPV, Agrotecnio Center, Escola Tècnica Superior d’Enginyeria Agrària, Food Technology Department, University of Lleida, Avda/Alcalde Rovira Roure 191, Lleida, 25198 Catalonia, Spain
7
Hospital Universitari Sant Joan de Reus, 43201 Reus, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Maria Cristina Mele
Nutrients 2021, 13(6), 2032; https://doi.org/10.3390/nu13062032
Received: 7 May 2021 / Revised: 2 June 2021 / Accepted: 11 June 2021 / Published: 13 June 2021
(This article belongs to the Section Nutrition and Metabolism)
We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positively associated with Collinsella aerofaciens, Dorea formicigenerans and Dorea longicatena, which had higher abundance the overweight/obese subjects. Moreover, different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. Saturated fatty acids (SFAs) were negatively associated with the genus Intestinimonas, a biomarker of the overweight/obese group, whereas SFAs were positively associated with Roseburia, a biomarker for the lean group. In conclusion, Dorea formicigenerans, Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers, Lachnospiraceae is associated with lipid cardiovascular risk factors. SFAs exhibited opposite association profiles with butyrate-producing bacteria depending on the BMI. Thus, the relationship between diet and microbiota opens new tools for the management of obesity. View Full-Text
Keywords: obesity; gut microbiota; dietary intake; saturated fatty acids obesity; gut microbiota; dietary intake; saturated fatty acids
Show Figures

Graphical abstract

MDPI and ACS Style

Companys, J.; Gosalbes, M.J.; Pla-Pagà, L.; Calderón-Pérez, L.; Llauradó, E.; Pedret, A.; Valls, R.M.; Jiménez-Hernández, N.; Sandoval-Ramirez, B.A.; del Bas, J.M.; Caimari, A.; Rubió, L.; Solà, R. Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study. Nutrients 2021, 13, 2032. https://doi.org/10.3390/nu13062032

AMA Style

Companys J, Gosalbes MJ, Pla-Pagà L, Calderón-Pérez L, Llauradó E, Pedret A, Valls RM, Jiménez-Hernández N, Sandoval-Ramirez BA, del Bas JM, Caimari A, Rubió L, Solà R. Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study. Nutrients. 2021; 13(6):2032. https://doi.org/10.3390/nu13062032

Chicago/Turabian Style

Companys, Judit, Maria J. Gosalbes, Laura Pla-Pagà, Lorena Calderón-Pérez, Elisabet Llauradó, Anna Pedret, Rosa M. Valls, Nuria Jiménez-Hernández, Berner A. Sandoval-Ramirez, Josep M. del Bas, Antoni Caimari, Laura Rubió, and Rosa Solà. 2021. "Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study" Nutrients 13, no. 6: 2032. https://doi.org/10.3390/nu13062032

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop