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Article

Lifetime Weight Course as a Phenotypic Marker of Severity and Therapeutic Response in Patients with Eating Disorders

1
Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 08907 L’Hospitalet de Llobregat, Spain
2
Department of Psychiatry, University Hospital of Bellvitge, 08907 L’Hospitalet de Llobregat, Spain
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Psychiatry and Mental Health Group, Neuroscience Program, Institut d’Investigació Biomèdica de Bellvitge—IDIBELL, 08907 L’Hospitalet de Llobregat, Spain
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Department of Public Health, Mental Health and Maternal-Child Nursing, School of Nursing, University of Barcelona, 08907 L’Hospitalet de Llobregat, Spain
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Departament de Psicobiologia i Metodologia de les Ciències de la Salut, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain
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Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, 08907 L’Hospitalet de Llobregat, Spain
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Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 08907 L’Hospitalet de Llobregat, Spain
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Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London WC2R 2LS, UK
*
Authors to whom correspondence should be addressed.
Academic Editor: Lidia Santarpia
Nutrients 2021, 13(6), 2034; https://doi.org/10.3390/nu13062034
Received: 29 April 2021 / Revised: 5 June 2021 / Accepted: 10 June 2021 / Published: 13 June 2021
(This article belongs to the Special Issue Eating Disorders and Obesity: Through the Life Course)
The association between lifetime weight fluctuations and clinical characteristics has been widely studied in populations with eating disorders (ED). However, there is a lack of literature examining the potential role of weight course as a transdiagnostic factor in ED so far. Therefore, the aim of this study is to compare ED severity and treatment outcomes among four specific BMI profiles based on BMI-trajectories across the lifespan: (a) persistent obesity (OB-OB; (n = 74)), (b) obesity in the past but currently in a normal weight range (OB-NW; n = 156), (c) normal weight throughout the lifespan (NW-NW; n = 756), and (d) current obesity but previously at normal weight (NW-OB; n = 314). Lifetime obesity is associated with greater general psychopathology and personality traits such as low persistence and self-directedness, and high reward dependence. Additionally, greater extreme weight changes (NW-OB and OB-NW) were associated with higher psychopathology but not with greater ED severity. Higher dropout rates were found in the OB-OB group. These results shed new light on the BMI trajectory as a transdiagnostic feature playing a pivotal role in the severity and treatment outcome in patients with ED. View Full-Text
Keywords: body mass index (BMI) profiles; eating disorders; obesity; treatment outcome body mass index (BMI) profiles; eating disorders; obesity; treatment outcome
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MDPI and ACS Style

Agüera, Z.; Vintró-Alcaraz, C.; Baenas, I.; Granero, R.; Sánchez, I.; Sánchez-González, J.; Menchón, J.M.; Jiménez-Murcia, S.; Treasure, J.; Fernández-Aranda, F. Lifetime Weight Course as a Phenotypic Marker of Severity and Therapeutic Response in Patients with Eating Disorders. Nutrients 2021, 13, 2034. https://doi.org/10.3390/nu13062034

AMA Style

Agüera Z, Vintró-Alcaraz C, Baenas I, Granero R, Sánchez I, Sánchez-González J, Menchón JM, Jiménez-Murcia S, Treasure J, Fernández-Aranda F. Lifetime Weight Course as a Phenotypic Marker of Severity and Therapeutic Response in Patients with Eating Disorders. Nutrients. 2021; 13(6):2034. https://doi.org/10.3390/nu13062034

Chicago/Turabian Style

Agüera, Zaida, Cristina Vintró-Alcaraz, Isabel Baenas, Roser Granero, Isabel Sánchez, Jéssica Sánchez-González, José M. Menchón, Susana Jiménez-Murcia, Janet Treasure, and Fernando Fernández-Aranda. 2021. "Lifetime Weight Course as a Phenotypic Marker of Severity and Therapeutic Response in Patients with Eating Disorders" Nutrients 13, no. 6: 2034. https://doi.org/10.3390/nu13062034

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