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Article

The Effects of High-Protein Diet and Resistance Training on Glucose Control and Inflammatory Profile of Visceral Adipose Tissue in Rats

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Programa de Pós-Graduação em Saúde e Desenvolvimento na Região Centro-Oeste, Faculdade de Medicina, Universidade Federal de Mato Grosso do Sul, Campo Grande 79070-900, Brazil
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Laboratório de Análises Moleculares, Programa de Pós-Graduação em Ciências e Tecnologias em Saúde, Universidade de Brasília, Distrito Federal 72220-275, Brazil
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Research in Exercise and Nutrition in Health and Sports Performance—PENSARE, Graduate Program in Movement Sciences, Universidade Federal de Mato Grosso do Sul, Campo Grande 79070-900, Brazil
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Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Distrito Federal 70790-160, Brazil
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Programa de Pós-Graduação em Ciências da Saúde, Universidade de Brasília, Distrito Federal 70910-900, Brazil
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S-Inova Biotech, Porgrama de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande 79117-900, Brazil
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Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil
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Department of Life Science, Whitelands College, University of Roehampton, London SW15 4DJ, UK
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Author to whom correspondence should be addressed.
Academic Editors: Roberta Ceci and Guglielmo Duranti
Nutrients 2021, 13(6), 1969; https://doi.org/10.3390/nu13061969
Received: 23 April 2021 / Revised: 22 May 2021 / Accepted: 25 May 2021 / Published: 8 June 2021
(This article belongs to the Collection The Role of Nutrition in Exercise and Sports)
High-protein diets (HPDs) are widely accepted as a way to stimulate muscle protein synthesis when combined with resistance training (RT). However, the effects of HPDs on adipose tissue plasticity and local inflammation are yet to be determined. This study investigated the impact of HPDs on glucose control, adipocyte size, and epididymal adipose inflammatory biomarkers in resistance-trained rats. Eighteen Wistar rats were randomly assigned to four groups: normal-protein (NPD; 17% protein total dietary intake) and HPD (26.1% protein) without RT and NPD and HPD with RT. Trained groups received RT for 12 weeks with weights secured to their tails. Glucose and insulin tolerance tests, adipocyte size, and an array of cytokines were determined. While HPD without RT induced glucose intolerance, enlarged adipocytes, and increased TNF-α, MCP-1, and IL1-β levels in epididymal adipose tissue (p < 0.05), RT diminished these deleterious effects, with the HPD + RT group displaying improved blood glucose control without inflammatory cytokine increases in epididymal adipose tissue (p < 0.05). Furthermore, RT increased glutathione expression independent of diet (p < 0.05). RT may offer protection against adipocyte hypertrophy, pro-inflammatory states, and glucose intolerance during HPDs. The results highlight the potential protective effects of RT to mitigate the maladaptive effects of HPDs. View Full-Text
Keywords: dietary management; exercise training; metabolism; adipokines dietary management; exercise training; metabolism; adipokines
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MDPI and ACS Style

Medeiros, C.S.; de Sousa Neto, I.V.; Silva, K.K.S.; Cantuária, A.P.C.; Rezende, T.M.B.; Franco, O.L.; de Cassia Marqueti, R.; Freitas-Lima, L.C.; Araujo, R.C.; Yildirim, A.; Mackenzie, R.; Alves Almeida, J. The Effects of High-Protein Diet and Resistance Training on Glucose Control and Inflammatory Profile of Visceral Adipose Tissue in Rats. Nutrients 2021, 13, 1969. https://doi.org/10.3390/nu13061969

AMA Style

Medeiros CS, de Sousa Neto IV, Silva KKS, Cantuária APC, Rezende TMB, Franco OL, de Cassia Marqueti R, Freitas-Lima LC, Araujo RC, Yildirim A, Mackenzie R, Alves Almeida J. The Effects of High-Protein Diet and Resistance Training on Glucose Control and Inflammatory Profile of Visceral Adipose Tissue in Rats. Nutrients. 2021; 13(6):1969. https://doi.org/10.3390/nu13061969

Chicago/Turabian Style

Medeiros, Claudia Stela, Ivo Vieira de Sousa Neto, Keemilyn Karla Santos Silva, Ana Paula Castro Cantuária, Taia Maria Berto Rezende, Octávio Luiz Franco, Rita de Cassia Marqueti, Leandro Ceotto Freitas-Lima, Ronaldo Carvalho Araujo, Azize Yildirim, Richard Mackenzie, and Jeeser Alves Almeida. 2021. "The Effects of High-Protein Diet and Resistance Training on Glucose Control and Inflammatory Profile of Visceral Adipose Tissue in Rats" Nutrients 13, no. 6: 1969. https://doi.org/10.3390/nu13061969

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