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Article

Resting Energy Expenditure Is Elevated in Asthma

1
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
2
Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
3
Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Jose Lara
Nutrients 2021, 13(4), 1065; https://doi.org/10.3390/nu13041065
Received: 1 February 2021 / Revised: 16 March 2021 / Accepted: 19 March 2021 / Published: 25 March 2021
Background: Asthma physiology affects respiratory function and inflammation, factors that may contribute to elevated resting energy expenditure (REE) and altered body composition. Objective: We hypothesized that asthma would present with elevated REE compared to weight-matched healthy controls. Methods: Adults with asthma (n = 41) and healthy controls (n = 20) underwent indirect calorimetry to measure REE, dual-energy X-ray absorptiometry (DEXA) to measure body composition, and 3-day diet records. Clinical assessments included spirometry, fractional exhaled nitric oxide (FENO), and a complete blood count. Results: Asthmatics had greater REE than controls amounting to an increase of ~100 kcals/day, even though body mass index (BMI) and body composition were similar between groups. Inclusion of asthma status and FENO in validated REE prediction equations led to improved estimates. Further, asthmatics had higher white blood cell (control vs. asthma (mean ± SD): 4.7 ± 1.1 vs. 5.9 ± 1.6, p < 0.01) and neutrophil (2.8 ± 0.9 vs. 3.6 ± 1.4, p = 0.02) counts that correlated with REE (both p < 0.01). Interestingly, despite higher REE, asthmatics reported consuming fewer calories (25.1 ± 7.5 vs. 20.3 ± 6.0 kcals/kg/day, p < 0.01) and carbohydrates than controls. Conclusion: REE is elevated in adults with mild asthma, suggesting there is an association between REE and the pathophysiology of asthma. View Full-Text
Keywords: resting energy expenditure; body composition; nutrition; respiratory function; airway inflammation resting energy expenditure; body composition; nutrition; respiratory function; airway inflammation
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MDPI and ACS Style

Mey, J.T.; Matuska, B.; Peterson, L.; Wyszynski, P.; Koo, M.; Sharp, J.; Pennington, E.; McCarroll, S.; Micklewright, S.; Zhang, P.; Aronica, M.; Hoddy, K.K.; Champagne, C.M.; Heymsfield, S.B.; Comhair, S.A.A.; Kirwan, J.P.; Erzurum, S.C.; Mulya, A. Resting Energy Expenditure Is Elevated in Asthma. Nutrients 2021, 13, 1065. https://doi.org/10.3390/nu13041065

AMA Style

Mey JT, Matuska B, Peterson L, Wyszynski P, Koo M, Sharp J, Pennington E, McCarroll S, Micklewright S, Zhang P, Aronica M, Hoddy KK, Champagne CM, Heymsfield SB, Comhair SAA, Kirwan JP, Erzurum SC, Mulya A. Resting Energy Expenditure Is Elevated in Asthma. Nutrients. 2021; 13(4):1065. https://doi.org/10.3390/nu13041065

Chicago/Turabian Style

Mey, Jacob T., Brittany Matuska, Laura Peterson, Patrick Wyszynski, Michelle Koo, Jacqueline Sharp, Emily Pennington, Stephanie McCarroll, Sarah Micklewright, Peng Zhang, Mark Aronica, Kristin K. Hoddy, Catherine M. Champagne, Steven B. Heymsfield, Suzy A.A. Comhair, John P. Kirwan, Serpil C. Erzurum, and Anny Mulya. 2021. "Resting Energy Expenditure Is Elevated in Asthma" Nutrients 13, no. 4: 1065. https://doi.org/10.3390/nu13041065

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