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Oral Nutritional Supplements in Adults with Cystic Fibrosis: Effects on Intake, Levels of Fat-Soluble Vitamins, and Bone Remodeling Biomarkers

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Servicio de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga/Universidad de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga 29008, Spain
2
Servicio de Neumología, Hospital Regional Universitario de Málaga/Universidad de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga 29008, Spain
3
Centro de Investigación Biomédica en Red-Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Barcelona 08036, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Roberto Iacone
Nutrients 2021, 13(2), 669; https://doi.org/10.3390/nu13020669
Received: 22 January 2021 / Accepted: 10 February 2021 / Published: 19 February 2021
(This article belongs to the Special Issue Nutrition and Cystic Fibrosis)
Background: The use of oral nutritional supplements (ONS) is common practice in patients suffering from cystic fibrosis (CF). We aimed to describe the rate of ONS use to assess their contribution to dietary intake and to determine if they are associated with respiratory status, body composition, muscle strength, bone mineral density (BMD), bone remodeling biomarkers, and plasmatic levels of vitamins. Methods: Cross-sectional study. Patients were clinically stable adults recruited from the CF unit. A 4-day prospective dietary questionnaire was conducted; in addition to respiratory variables, body composition, and BMD (through densitometry, DXA), muscle strength (JAMAR dynamometer), fat-soluble vitamins, and bone remodeling biomarkers (vitamins A, D, and E; osteocalcin, OC; undercarboxylated osteocalcin, ucOC; degradation of the C-terminal telopeptides of type I collagen, CTX; and receptor activator of nuclear factor-kappaB ligand, RANKL) were also evaluated. Results: The study included 59 subjects with CF (57.6% female, mean age 29.3 ± 9.4 years, and BMI 22.0 ± 3.6 kg/m2). In this study, 22% (13) patients were taking ONS and presented, compared with those not taking them, significantly more total and mild exacerbations and lower BMI; moreover, they showed a significantly higher total daily calorie intake in addition to a higher consumption of carbohydrates, proteins, and lipids per kg of body weight, omega-3 fatty acids, and vitamins A, D, and E. Vitamin E plasmatic levels were significantly higher in the group on ONS, as was the case with RANKL; finally, a lower rate of vitamin D deficiency was also found. Conclusions: ONS were used by patients with worse respiratory and nutritional statuses and their use was associated with a higher intake of macro- and micronutrients and with better plasmatic levels of fat-soluble vitamins. View Full-Text
Keywords: cystic fibrosis; oral nutritional supplements (ONS); nutrition; malnutrition cystic fibrosis; oral nutritional supplements (ONS); nutrition; malnutrition
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MDPI and ACS Style

Contreras-Bolívar, V.; Olveira, C.; Porras, N.; Abuín-Fernández, J.; García-Olivares, M.; Sánchez-Torralvo, F.J.; Girón, M.V.; Ruiz-García, I.; Olveira, G. Oral Nutritional Supplements in Adults with Cystic Fibrosis: Effects on Intake, Levels of Fat-Soluble Vitamins, and Bone Remodeling Biomarkers. Nutrients 2021, 13, 669. https://doi.org/10.3390/nu13020669

AMA Style

Contreras-Bolívar V, Olveira C, Porras N, Abuín-Fernández J, García-Olivares M, Sánchez-Torralvo FJ, Girón MV, Ruiz-García I, Olveira G. Oral Nutritional Supplements in Adults with Cystic Fibrosis: Effects on Intake, Levels of Fat-Soluble Vitamins, and Bone Remodeling Biomarkers. Nutrients. 2021; 13(2):669. https://doi.org/10.3390/nu13020669

Chicago/Turabian Style

Contreras-Bolívar, Victoria, Casilda Olveira, Nuria Porras, José Abuín-Fernández, María García-Olivares, Francisco J. Sánchez-Torralvo, María V. Girón, Ignacio Ruiz-García, and Gabriel Olveira. 2021. "Oral Nutritional Supplements in Adults with Cystic Fibrosis: Effects on Intake, Levels of Fat-Soluble Vitamins, and Bone Remodeling Biomarkers" Nutrients 13, no. 2: 669. https://doi.org/10.3390/nu13020669

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