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Article

Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity

1
Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario, 29010 Málaga, Spain
2
Departamento de Bioquímica Médica, Biología Molecular e Inmunología, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain
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Instituto de Investigación Biomédica de Málaga-IBIMA, 29010 Málaga, Spain
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CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), 29009 Málaga, Spain
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Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
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Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain
7
Faculty of Health Sciences, School of Medicine, University of Málaga, 29071 Málaga, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
Nutrients 2021, 13(2), 436; https://doi.org/10.3390/nu13020436
Received: 28 November 2020 / Revised: 21 January 2021 / Accepted: 25 January 2021 / Published: 29 January 2021
(This article belongs to the Section Nutritional Epidemiology)
Background: The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). Methods: We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. Results: There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). Conclusions: There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food. View Full-Text
Keywords: Mediterranean diet; metabolic syndrome; miRNA; morbid obesity; type 2 diabetes mellitus Mediterranean diet; metabolic syndrome; miRNA; morbid obesity; type 2 diabetes mellitus
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MDPI and ACS Style

Fontalba-Romero, M.I.; Lopez-Enriquez, S.; Lago-Sampedro, A.; García-Escobar, E.; Pastori, R.L.; Domínguez-Bendala, J.; Álvarez-Cubela, S.; Valdes, S.; Rojo, G.; Garcia-Fuentes, E.; Labajos-Manzanares, M.T.; García-Serrano, S. Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity. Nutrients 2021, 13, 436. https://doi.org/10.3390/nu13020436

AMA Style

Fontalba-Romero MI, Lopez-Enriquez S, Lago-Sampedro A, García-Escobar E, Pastori RL, Domínguez-Bendala J, Álvarez-Cubela S, Valdes S, Rojo G, Garcia-Fuentes E, Labajos-Manzanares MT, García-Serrano S. Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity. Nutrients. 2021; 13(2):436. https://doi.org/10.3390/nu13020436

Chicago/Turabian Style

Fontalba-Romero, María I., Soledad Lopez-Enriquez, Ana Lago-Sampedro, Eva García-Escobar, Ricardo L. Pastori, Juan Domínguez-Bendala, Silvia Álvarez-Cubela, Sergio Valdes, Gemma Rojo, Eduardo Garcia-Fuentes, María T. Labajos-Manzanares, and Sara García-Serrano. 2021. "Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity" Nutrients 13, no. 2: 436. https://doi.org/10.3390/nu13020436

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