Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity

Background: The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). Methods: We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. Results: There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). Conclusions: There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food. View Full-Text

Keywords: Mediterranean diet; metabolic syndrome; miRNA; morbid obesity; type 2 diabetes mellitus

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Fontalba-Romero, M.I.; Lopez-Enriquez, S.; Lago-Sampedro, A.; García-Escobar, E.; Pastori, R.L.; Domínguez-Bendala, J.; Álvarez-Cubela, S.; Valdes, S.; Rojo, G.; Garcia-Fuentes, E.; Labajos-Manzanares, M.T.; García-Serrano, S. Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity. Nutrients 2021, 13, 436. https://doi.org/10.3390/nu13020436

AMA Style

Fontalba-Romero MI, Lopez-Enriquez S, Lago-Sampedro A, García-Escobar E, Pastori RL, Domínguez-Bendala J, Álvarez-Cubela S, Valdes S, Rojo G, Garcia-Fuentes E, Labajos-Manzanares MT, García-Serrano S. Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity. Nutrients. 2021; 13(2):436. https://doi.org/10.3390/nu13020436

Chicago/Turabian Style

Fontalba-Romero, María I., Soledad Lopez-Enriquez, Ana Lago-Sampedro, Eva García-Escobar, Ricardo L. Pastori, Juan Domínguez-Bendala, Silvia Álvarez-Cubela, Sergio Valdes, Gemma Rojo, Eduardo Garcia-Fuentes, María T. Labajos-Manzanares, and Sara García-Serrano. 2021. "Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity" Nutrients 13, no. 2: 436. https://doi.org/10.3390/nu13020436

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Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity

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