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Article

Synbiotic Effect of Bifidobacterium lactis CNCM I-3446 and Bovine Milk-Derived Oligosaccharides on Infant Gut Microbiota

1
Center for Microbial Ecology and Technology (CMET), Department of Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
2
ProDigest BV, Technologiepark 82, 9052 Ghent, Belgium
3
Nestlé Research and Development Konolfingen, Nestléstrasse 3, 3510 Konolfingen, Switzerland
4
Nestlé Research, Route du Jorat 57, 1000 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(8), 2268; https://doi.org/10.3390/nu12082268
Received: 13 July 2020 / Revised: 27 July 2020 / Accepted: 27 July 2020 / Published: 29 July 2020
(This article belongs to the Special Issue Human Milk, HMO, Lactation and Application in Infant Feeding)
Background: This study evaluated the impact of Bifidobacterium animalis ssp. lactis CNCM I-3446, Bovine Milk-derived OligoSaccharides (BMOS) and their combination on infant gut microbiota in vitro. In addition, a novel strategy consisting of preculturing B. lactis with BMOS to further enhance their potential synbiotic effects was assessed. Method: Short-term fecal batch fermentations (48 h) were used to assess the microbial composition and activity modulated by BMOS alone, B. lactis grown on BMOS or dextrose alone, or their combinations on different three-month-old infant microbiota. Results: BMOS alone significantly induced acetate and lactate production (leading to pH decrease) and stimulated bifidobacterial growth in 10 donors. A further in-depth study on two different donors proved B. lactis ability to colonize the infant microbiota, regardless of the competitiveness of the environment. BMOS further enhanced this engraftment, suggesting a strong synbiotic effect. This was also observed at the microbiota activity level, especially in a donor containing low initial levels of bifidobacteria. In this donor, preculturing B. lactis with BMOS strengthened further the early modulation of microbiota activity observed after 6 h. Conclusion: This study demonstrated the strong synbiotic effect of BMOS and B. lactis on the infant gut microbiota, and suggests a strategy to improve its effectiveness in an otherwise low-Bifidobacterium microbiota. View Full-Text
Keywords: infant gut microbiota; Bifidobacterium animalis ssp. lactis; BMOS; in vitro fermentation; probiotic; prebiotic; dysbiosis; preculturing; synbiotic; oligosaccharides infant gut microbiota; Bifidobacterium animalis ssp. lactis; BMOS; in vitro fermentation; probiotic; prebiotic; dysbiosis; preculturing; synbiotic; oligosaccharides
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MDPI and ACS Style

Marsaux, B.; Van den Abbeele, P.; Ghyselinck, J.; Prioult, G.; Marzorati, M.; Bogićević, B. Synbiotic Effect of Bifidobacterium lactis CNCM I-3446 and Bovine Milk-Derived Oligosaccharides on Infant Gut Microbiota. Nutrients 2020, 12, 2268. https://doi.org/10.3390/nu12082268

AMA Style

Marsaux B, Van den Abbeele P, Ghyselinck J, Prioult G, Marzorati M, Bogićević B. Synbiotic Effect of Bifidobacterium lactis CNCM I-3446 and Bovine Milk-Derived Oligosaccharides on Infant Gut Microbiota. Nutrients. 2020; 12(8):2268. https://doi.org/10.3390/nu12082268

Chicago/Turabian Style

Marsaux, Benoît, Pieter Van den Abbeele, Jonas Ghyselinck, Guénolée Prioult, Massimo Marzorati, and Biljana Bogićević. 2020. "Synbiotic Effect of Bifidobacterium lactis CNCM I-3446 and Bovine Milk-Derived Oligosaccharides on Infant Gut Microbiota" Nutrients 12, no. 8: 2268. https://doi.org/10.3390/nu12082268

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