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Open AccessArticle

Discovery of a Novel Multi-Strains Probiotic Formulation with Improved Efficacy toward Intestinal Inflammation

1
Department of Surgical and Biomedical Sciences, University of Perugia, via L. Severi 1, 06132 Perugia, Italy
2
Department of Pharmacy, University of Naples "Federico II", via D. Montesano 49, 80131 Naples, Italy
3
Azienda ospedaliera di Perugia, 06132 Perugia, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(7), 1945; https://doi.org/10.3390/nu12071945
Received: 16 June 2020 / Revised: 24 June 2020 / Accepted: 29 June 2020 / Published: 30 June 2020
(This article belongs to the Section Prebiotics and Probiotics)
Dysbiosis is commonly detected in patients with inflammatory bowel disease (IBD), supporting the concept that a dysregulated immune reaction to bacterial antigens has a pathogenic role in the development of intestinal inflammation. In the present study, we have investigated the beneficial effects of a novel probiotic formulation assembled by combining four probiotics (Streptococcus thermophilus, Lactobacillus casei, Bifidobacterium breve, Bifidobacterium animalis subsp. Lactis) with Bacillus subtilis, a Gram-positive bacterium, with extensive bio-applications. Mice rendered colitic by administration of TNBS or DSS were administered with Bacillus subtilis alone, Vivomixx® or the novel Five strains formulation. Vivomixx® attenuated the severity of inflammation and reduced the development of signs and symptoms of colitis in both models. Adding Bacillus subtilis to Vivomixx® improved the beneficial effects of the bacterial therapy. The novel Five strains formulation was as effective as Vivomixx® in reducing the development of signs and symptoms of colitis and reduced the expression of pro-inflammatory mediators including Il-6 and Tnf-α while increased the expression of Il-10 mRNA and the number of Treg. In summary, we have shown that a novel Five strains probiotics formulation exerts beneficial effects on two chemical models of colitis, establishing Bacillus subtilis as a probiotic in rodent models of inflammation. View Full-Text
Keywords: probiotics; inflammatory bowel disease; animal studies; cytokines and inflammation; treg probiotics; inflammatory bowel disease; animal studies; cytokines and inflammation; treg
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MDPI and ACS Style

Biagioli, M.; Carino, A.; Di Giorgio, C.; Marchianò, S.; Bordoni, M.; Roselli, R.; Distrutti, E.; Fiorucci, S. Discovery of a Novel Multi-Strains Probiotic Formulation with Improved Efficacy toward Intestinal Inflammation. Nutrients 2020, 12, 1945.

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