Next Article in Journal
Dietary Habits and Nutrition in Rheumatoid Arthritis: Can Diet Influence Disease Development and Clinical Manifestations?
Next Article in Special Issue
Interaction between Metabolic Genetic Risk Score and Dietary Fatty Acid Intake on Central Obesity in a Ghanaian Population
Previous Article in Journal
The Effects on Immune Function and Digestive Health of Consuming the Skin and Flesh of Zespri® SunGold Kiwifruit (Actinidia Chinensis var. Chinensis ‘Zesy002’) in Healthy and IBS-Constipated Individuals
Previous Article in Special Issue
A Nutrigenetic Approach to Investigate the Relationship between Metabolic Traits and Vitamin D Status in an Asian Indian Population
Open AccessArticle

Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant MTHFD1-rs2236225 on Homocysteine Levels

1
School of Environmental & Life Sciences, University of Newcastle, Ourimbah, NSW 2258, Australia
2
Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia
3
Nutraceuticals Research Group, University of Newcastle, Callaghan, NSW 2308, Australia
4
Riddet Institute, Massey University, Palmerston North 4442, New Zealand
5
Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia
6
Hull-York Medical School, University of Hull, Hull YO10 5DD, UK
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1455; https://doi.org/10.3390/nu12051455
Received: 15 April 2020 / Revised: 11 May 2020 / Accepted: 14 May 2020 / Published: 18 May 2020
(This article belongs to the Special Issue Nutrient Gene Interactions)
Elevated homocysteine (Hcy) levels are a risk factor for vascular diseases. Recently, increases in ultraviolet radiation (UVR) have been linked to decreased Hcy levels. This relationship may be mediated by the status of UVR-responsive vitamins, vitamin D and folate, and/or genetic variants influencing their levels; however, this has yet to be examined. Therefore, the independent and interactive influences of environmental UVR, vitamin D and folate levels and related genetic variants on Hcy levels were examined in an elderly Australian cohort (n = 619). Red blood cell folate, 25-hydroxyvitamin D (25(OH)D), and plasma Hcy levels were determined, and genotyping for 21 folate and vitamin D-related variants was performed. Erythemal dose rate accumulated over six-weeks (6W-EDR) and four-months (4M-EDR) prior to clinics were calculated as a measure of environmental UVR. Multivariate analyses found interactions between 6W-EDR and 25(OH)D levels (pinteraction = 0.002), and 4M-EDR and MTHFD1-rs2236225 (pinteraction = 0.006) in predicting Hcy levels. The association between 6W-EDR and Hcy levels was found only in subjects within lower 25(OH)D quartiles (<33.26 ng/mL), with the association between 4M-EDR and Hcy occurring only in subjects carrying the MTHFD1-rs2236225 variant. 4M-EDR, 6W-EDR, and MTHFD1-rs2236225 were also independent predictors of Hcy. Findings highlight nutrient–environment and gene–environment interactions that could influence the risk of Hcy-related outcomes. View Full-Text
Keywords: homocysteine; folate; vitamin D; ultraviolet radiation; genetic variant homocysteine; folate; vitamin D; ultraviolet radiation; genetic variant
Show Figures

Figure 1

MDPI and ACS Style

Jones, P.; Lucock, M.; Martin, C.; Thota, R.; Garg, M.; Yates, Z.; Scarlett, C.J.; Veysey, M.; Beckett, E. Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant MTHFD1-rs2236225 on Homocysteine Levels. Nutrients 2020, 12, 1455.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop