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Naturally Occurring PCSK9 Inhibitors

Department of Medicine and Surgery-Unit of Neurosciences, University of Parma, 43125 Parma, Italy
Dipartimento di Scienze degli Alimenti e del Farmaco, Università di Parma, 43124 Parma, Italy
Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, 35121 Padova, Italy
Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20122 Milan, Italy
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1440;
Received: 20 April 2020 / Revised: 12 May 2020 / Accepted: 13 May 2020 / Published: 16 May 2020
(This article belongs to the Special Issue Diets, Foods and Food Components Effect on Dyslipidemia)
Genetic, epidemiological and pharmacological data have led to the conclusion that antagonizing or inhibiting Proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces cardiovascular events. This clinical outcome is mainly related to the pivotal role of PCSK9 in controlling low-density lipoprotein (LDL) cholesterol levels. The absence of oral and affordable anti-PCSK9 medications has limited the beneficial effects of this new therapeutic option. A possible breakthrough in this field may come from the discovery of new naturally occurring PCSK9 inhibitors as a starting point for the development of oral, small molecules, to be used in combination with statins in order to increase the percentage of patients reaching their LDL-cholesterol target levels. In the present review, we have summarized the current knowledge on natural compounds or extracts that have shown an inhibitory effect on PCSK9, either in experimental or clinical settings. When available, the pharmacodynamic and pharmacokinetic profiles of the listed compounds are described. View Full-Text
Keywords: nutraceuticals; PCSK9; SREBP; HNF1α; berberine; cholesterol nutraceuticals; PCSK9; SREBP; HNF1α; berberine; cholesterol
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MDPI and ACS Style

Adorni, M.P.; Zimetti, F.; Lupo, M.G.; Ruscica, M.; Ferri, N. Naturally Occurring PCSK9 Inhibitors. Nutrients 2020, 12, 1440.

AMA Style

Adorni MP, Zimetti F, Lupo MG, Ruscica M, Ferri N. Naturally Occurring PCSK9 Inhibitors. Nutrients. 2020; 12(5):1440.

Chicago/Turabian Style

Adorni, Maria P., Francesca Zimetti, Maria G. Lupo, Massimiliano Ruscica, and Nicola Ferri. 2020. "Naturally Occurring PCSK9 Inhibitors" Nutrients 12, no. 5: 1440.

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