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Open AccessArticle

Increased Susceptibility to Obesity and Glucose Intolerance in Adult Female Rats Programmed by High-Protein Diet during Gestation, But Not during Lactation

1
Université Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, 75005 Paris, France
2
Danone Nutricia Research, 3584 CT Utrecht, The Netherlands
3
Université Paris-Saclay, AgroParisTech, INRAE, UMR MIA-Paris, 75005 Paris, France
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 315; https://doi.org/10.3390/nu12020315
Received: 11 December 2019 / Revised: 16 January 2020 / Accepted: 21 January 2020 / Published: 25 January 2020
(This article belongs to the Section Nutrition and Metabolism)
Fetal and early postnatal nutritional environments contribute to lifelong health. High-protein (HP) intake in early life can increase obesity risk in response to specific feeding conditions after weaning. This study investigated the effects of a maternal HP diet during pregnancy and/or lactation on the metabolic health of offspring. Three groups of dams received a normal-protein (NP, 20E% proteins) diet during gestation and lactation (Control group), an HP diet (55E% proteins) during gestation (HPgest group), or an HP diet during lactation (HPlact group). From weaning until 10 weeks, female pups were exposed to the NP, the HP or the western (W) diet. HPgest pups had more adipocytes (p = 0.009), more subcutaneous adipose tissue (p = 0.04) and increased expression of genes involved in liver fatty acid synthesis at 10 weeks (p < 0.05). HPgest rats also showed higher food intake and adiposity under the W diet compared to the Control and HPlact rats (p 0.04). The post-weaning HP diet reduced weight (p < 0.0001), food intake (p < 0.0001), adiposity (p < 0.0001) and glucose tolerance (p < 0.0001) compared to the NP and W diets; this effect was enhanced in the HPgest group (p = 0.04). These results show that a maternal HP diet during gestation, but not lactation, leads to a higher susceptibility to obesity and glucose intolerance in female offspring.
Keywords: high-protein; perinatal; obesity risk high-protein; perinatal; obesity risk
MDPI and ACS Style

Desclée de Maredsous, C.; Carlin, G.; Oosting, A.; Delteil, C.; Azzout-Marniche, D.; Chaumontet, C.; Blachier, F.; Barbillon, P.; Mary-Huard, T.; Tomé, D.; Oozeer, R.; Davila, A.-M. Increased Susceptibility to Obesity and Glucose Intolerance in Adult Female Rats Programmed by High-Protein Diet during Gestation, But Not during Lactation. Nutrients 2020, 12, 315.

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