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The Kidney–Gut–Muscle Axis in End-Stage Renal Disease is Similarly Represented in Older Adults

Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center (HNRCA), Tufts University, Boston, MA 02111, USA
Nutrients 2020, 12(1), 106; https://doi.org/10.3390/nu12010106
Received: 29 November 2019 / Revised: 26 December 2019 / Accepted: 27 December 2019 / Published: 30 December 2019
(This article belongs to the Special Issue Ageing and Sarcopenia: Effect of Community and Clinical Nutrition)
Decreased renal function, elevated circulating levels of urea, intestinal levels of urea-degrading bacteria, and gut-derived uremic metabolites are present in end-stage renal disease (ESRD), a cohort that has reduced muscle mass and physical function, and poor muscle composition. This phenotype, defined as the kidney–gut–muscle axis, is similarly represented in older adults that do not have ESRD. The purpose of this short communication is to illuminate these findings, and to propose a strategy that can positively impact the kidney–gut–muscle axis. For example, dietary fiber is fermented by intestinal bacteria, thereby producing the short-chain fatty acids (SCFAs) acetate, propionate, and butyrate, which affect each component of the kidney–gut–muscle axis. Accordingly, a high-fiber diet may be an important approach for improving the kidney–gut–muscle axis in ESRD and in older adults that do not have ESRD. View Full-Text
Keywords: ESRD; gut microbiome-derived uremic metabolites; aging; renal function; sarcopenia; muscle composition ESRD; gut microbiome-derived uremic metabolites; aging; renal function; sarcopenia; muscle composition
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MDPI and ACS Style

Lustgarten, M.S. The Kidney–Gut–Muscle Axis in End-Stage Renal Disease is Similarly Represented in Older Adults. Nutrients 2020, 12, 106.

AMA Style

Lustgarten MS. The Kidney–Gut–Muscle Axis in End-Stage Renal Disease is Similarly Represented in Older Adults. Nutrients. 2020; 12(1):106.

Chicago/Turabian Style

Lustgarten, Michael S. 2020. "The Kidney–Gut–Muscle Axis in End-Stage Renal Disease is Similarly Represented in Older Adults" Nutrients 12, no. 1: 106.

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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