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Open AccessArticle

Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults

1
School of Life and Environmental Sciences and Charles Perkins Centre, D17, The University of Sydney, Sydney, NSW 2006, Australia
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Euromed S.A., C/ Rec de Dalt, 21-23, Pol. Ind. Can Magarola, 08100 Mollet del Valles, Barcelona, Spain
3
Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, Australia
4
Smidt Labs, LLC, Sandy, UT 84092, USA
5
BioTherapeutics, Inc, 1800 Kraft Drive, Suite 200, Blacksburg, VA 24060, USA
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1757; https://doi.org/10.3390/nu11081757
Received: 30 June 2019 / Revised: 26 July 2019 / Accepted: 29 July 2019 / Published: 31 July 2019
(This article belongs to the Special Issue The Relationship between Glycemic Index and Human Health)
Abscisic acid (ABA) can improve glucose homeostasis and reduce inflammation in mammals by activating lanthionine synthetase C-like 2 (LANCL2). This study examined the effects of two fig fruit extracts (FFEs), each administered at two different ABA doses, on glycemic index (GI) and insulinemic index (II) to a standard glucose drink. In a randomized, double-blind crossover study, 10 healthy adults consumed 4 test beverages containing FFE with postprandial glucose and insulin assessed at regular intervals over 2 h to determine GI and II responses. Test beverages containing 200 mg FFE-50× and 1200 mg FFE-10× significantly reduced GI values by −25% (P = 0.001) and −24% (P = 0.002), respectively. Two lower doses of FFE also reduced GI values compared with the reference drink (by approximately −14%), but the differences did not reach statistical significance. Addition of FFE to the glucose solution significantly reduced II values at all dosages and displayed a clear dose-response reduction: FFE-50× at 100 mg and 200 mg (−14% (P < 0.05) and −24% (P = 0.01), respectively) and FFE-10× at 600 mg and 1200 mg (−16% (P < 0.05) and −24% (P = 0.01), respectively). FFE supplementation is a promising nutritional intervention for the management of acute postprandial glucose and insulin homeostasis, and it is a possible adjunctive treatment for glycemic management of chronic metabolic disorders such as prediabetes and type 2 diabetes mellitus. View Full-Text
Keywords: abscisic acid; fig fruit extract; glycemic index; insulinemic index abscisic acid; fig fruit extract; glycemic index; insulinemic index
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MDPI and ACS Style

Atkinson, F.S.; Villar, A.; Mulà, A.; Zangara, A.; Risco, E.; Smidt, C.R.; Hontecillas, R.; Leber, A.; Bassaganya-Riera, J. Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults. Nutrients 2019, 11, 1757. https://doi.org/10.3390/nu11081757

AMA Style

Atkinson FS, Villar A, Mulà A, Zangara A, Risco E, Smidt CR, Hontecillas R, Leber A, Bassaganya-Riera J. Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults. Nutrients. 2019; 11(8):1757. https://doi.org/10.3390/nu11081757

Chicago/Turabian Style

Atkinson, Fiona S.; Villar, Agusti; Mulà, Anna; Zangara, Andrea; Risco, Ester; Smidt, Carsten R.; Hontecillas, Raquel; Leber, Andrew; Bassaganya-Riera, Josep. 2019. "Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults" Nutrients 11, no. 8: 1757. https://doi.org/10.3390/nu11081757

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