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Open AccessArticle

Temporal Change in Biomarkers of Bone Turnover Following Late Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix in Postmenopausal Women with Osteopenia

Health Research Institute, University of Limerick, V94 T9PX Limerick, Ireland
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Nutrients 2019, 11(6), 1413; https://doi.org/10.3390/nu11061413
Received: 21 May 2019 / Revised: 18 June 2019 / Accepted: 19 June 2019 / Published: 23 June 2019
(This article belongs to the Special Issue Nutritional Status and Bone Health)
The diurnal rhythm of bone remodeling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of bedtime ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or maltodextrin (CON) on acute (0–4 h) blood and 24-h urinary change in biomarkers of bone remodeling in postmenopausal women with osteopenia. In CON, participants received 804 ± 52 mg calcium, 8.2 ± 3.2 µg vitamin D and 1.3 ± 0.2 g/kg BM protein per day. MBPM increased calcium intake to 1679 ± 196 mg, vitamin D to 9.2 ± 3.1 µg and protein to 1.6 ± 0.2 g/kg BM. Serum C-terminal cross-linked telopeptide of type I collagen (CTX) and procollagen type 1 amino-terminal propeptide (P1NP), and urinary N-telopeptide cross-links of type I collagen (NTX), pyridinoline (PYD) and deoxypyridinoline (DPD) was measured. Analyzed by AUC and compared to CON, a −32% lower CTX (p = 0.011, d = 0.83) and 24% (p = 0.52, d = 0.2) increase in P1NP was observed for MBPM. Mean total 24 h NTX excreted in MBPM was −10% (p = 0.035) lower than CON. Urinary PYD and DPD were unaffected by treatment. This study demonstrates the acute effects of bedtime ingestion of a calcium-fortified, milk-based protein matrix on bone remodeling. View Full-Text
Keywords: randomized control trial; milk protein matrix; nutrient intervention; nutrient timing; bone remodeling; bone turnover markers; bone health; osteopenia; postmenopausal women randomized control trial; milk protein matrix; nutrient intervention; nutrient timing; bone remodeling; bone turnover markers; bone health; osteopenia; postmenopausal women
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Hettiarachchi, M.; Cooke, R.; Norton, C.; Jakeman, P. Temporal Change in Biomarkers of Bone Turnover Following Late Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix in Postmenopausal Women with Osteopenia. Nutrients 2019, 11, 1413.

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