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Genetic and Non-Genetic Factor-Adjusted Association between Coffee Drinking and High-Density Lipoprotein Cholesterol in Taiwanese Adults: Stratification by Sex

1
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
2
Superintendent Office, Cathay General Hospital, Taipei 106, Taiwan
3
Department of Public Health, Institute of Public Health, Chung Shan Medical University, Taichung 40201, Taiwan
4
School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
5
Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(5), 1102; https://doi.org/10.3390/nu11051102
Received: 11 April 2019 / Revised: 26 April 2019 / Accepted: 14 May 2019 / Published: 17 May 2019
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Abstract

Low high-density lipoprotein cholesterol (HDL-C) is a major risk factor for cardiovascular diseases (CVDs), the leading cause of global mortality. We aimed to determine the effect of coffee drinking and sex and their interaction, as well as rs1800588 and rs1800775 polymorphisms on HDL-C levels in Taiwanese adults. Data of 4262 men and 4813 women, aged 30–70 years, were retrieved from Taiwan Biobank. The interaction between sex and coffee drinking on HDL-C was significant (p = 0.0452). Coffee consumption was significantly associated with higher HDL-C levels in only women (β = 0.81679; p = 0.0246). However, rs1800588 and rs1800775 variants were significantly associated with HDL-C in both sexes. In women, β-values were 0.99080; p = 0.0059 and 3.16277; p < 0.0001 for rs1800588 CT and TT genotypes, respectively and −1.80954; p < 0.0001 and −2.81512; p < 0.0001 for rs1800775 AC and CC genotypes, respectively. In men, β-values were 1.32430; p < 0.0001 and 3.24976; p < 0.0001 for rs1800775 CT and TT genotypes, respectively and −1.96232; p < 0.0001 and −2.71536, p < 0.0001 for the AC and CC genotypes, respectively. In conclusion, coffee drinking was significantly associated with higher high-density lipoprotein (HDL) levels in women but not men after adjusting for confounders including rs1800588 (LIPC) and rs1800775 (CETP) variants. View Full-Text
Keywords: HDL-C; coffee drinking; sex; Taiwan Biobank; rs1800588; rs180077 HDL-C; coffee drinking; sex; Taiwan Biobank; rs1800588; rs180077
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Hsu, T.-W.; Tantoh, D.M.; Lee, K.-J.; Ndi, O.N.; Lin, L.-Y.; Chou, M.-C.; Liaw, Y.-P. Genetic and Non-Genetic Factor-Adjusted Association between Coffee Drinking and High-Density Lipoprotein Cholesterol in Taiwanese Adults: Stratification by Sex. Nutrients 2019, 11, 1102.

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