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Article

Randomized Trial of Marine n-3 Polyunsaturated Fatty Acids for the Prevention of Cerebral Small Vessel Disease and Inflammation in Aging (PUFA Trial): Rationale, Design and Baseline Results

1
Interventional Studies in Aging Center, Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA
2
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
3
Department of Neurology, Oregon Health and Science University, Portland, OR 97219, USA
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Department of Neurology, Veterans Affairs Portland Health Care System, Portland, OR 97219, USA
5
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
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Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 735; https://doi.org/10.3390/nu11040735
Received: 1 February 2019 / Revised: 20 March 2019 / Accepted: 21 March 2019 / Published: 29 March 2019
(This article belongs to the Special Issue Lifestyle Strategies in Cognitive Decline: Focus on Nutrition)
Vascular risk factors for age-related cognitive decline are significant, and their management may ultimately prove the most successful strategy for reducing risk and sustaining cognitive health. This randomized, double-blinded, placebo-controlled trial with parallel group allocation to either marine n-3 polyunsaturated fatty acids (n-3 PUFA) or soybean oil placebo assesses the effects on the total volume of accumulation in cerebral white matter hyperintensities (WMH), a potentially modifiable neurovascular component of age-related cognitive decline. Total WMH accumulation over 3 years is the primary endpoint. The safety and efficacy of n-3 PUFA is evaluated in older adults with significant WMH and suboptimum plasma n-3 PUFA as inclusion criteria. One hundred and two non-demented older adults were enrolled with a mean age of 81.1 (±4.4) years, WMH of 19.4 (±16.1) cm3, and a plasma n-3 PUFA of 86.64 (±29.21) µg/mL. 61% were female, 28% were apolipoprotein E epsilon 4 carriers, and the mean mini-mental state exam (MMSE) was 27.9 (±1.7). This trial provides an initial evaluation of n-3 PUFA effects on WMH, a reproducible and valid risk biomarker for cognitive decline, as well as on inflammatory biomarkers thought to play a role in WMH accumulation. We present the baseline results and operational experience of enriching a study population on advanced age, blood n-3 PUFA, and magnetic resonance imaging (MRI) derived WMH with biomarker outcomes (WMH, inflammation markers) in a dementia prevention paradigm. View Full-Text
Keywords: white matter hyperintensities; cognitive decline; vascular cognitive impairment; executive function; eicosapentaenoic acid; docosahexaenoic acid; neuroimaging; MRI; elderly white matter hyperintensities; cognitive decline; vascular cognitive impairment; executive function; eicosapentaenoic acid; docosahexaenoic acid; neuroimaging; MRI; elderly
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MDPI and ACS Style

Bowman, G.L.; Silbert, L.C.; Dodge, H.H.; Lahna, D.; Hagen, K.; Murchison, C.F.; Howieson, D.; Kaye, J.; Quinn, J.F.; Shinto, L. Randomized Trial of Marine n-3 Polyunsaturated Fatty Acids for the Prevention of Cerebral Small Vessel Disease and Inflammation in Aging (PUFA Trial): Rationale, Design and Baseline Results. Nutrients 2019, 11, 735. https://doi.org/10.3390/nu11040735

AMA Style

Bowman GL, Silbert LC, Dodge HH, Lahna D, Hagen K, Murchison CF, Howieson D, Kaye J, Quinn JF, Shinto L. Randomized Trial of Marine n-3 Polyunsaturated Fatty Acids for the Prevention of Cerebral Small Vessel Disease and Inflammation in Aging (PUFA Trial): Rationale, Design and Baseline Results. Nutrients. 2019; 11(4):735. https://doi.org/10.3390/nu11040735

Chicago/Turabian Style

Bowman, Gene L., Lisa C. Silbert, Hiroko H. Dodge, David Lahna, Kirsten Hagen, Charles F. Murchison, Diane Howieson, Jeffrey Kaye, Joseph F. Quinn, and Lynne Shinto. 2019. "Randomized Trial of Marine n-3 Polyunsaturated Fatty Acids for the Prevention of Cerebral Small Vessel Disease and Inflammation in Aging (PUFA Trial): Rationale, Design and Baseline Results" Nutrients 11, no. 4: 735. https://doi.org/10.3390/nu11040735

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