Next Article in Journal
Lessons Learned from the Testing of Neonatal Vitamin A Supplementation
Next Article in Special Issue
Human Gut Microbiome Response Induced by Fermented Dairy Product Intake in Healthy Volunteers
Previous Article in Journal
Beverage Intake and Drinking Patterns—Clues to Support Older People Living in Long-Term Care to Drink Well: DRIE and FISE Studies
Previous Article in Special Issue
The Efficacy of Probiotics, Prebiotic Inulin-Type Fructans, and Synbiotics in Human Ulcerative Colitis: A Systematic Review and Meta-Analysis
Article

In Vitro Antimicrobial Activity and Probiotic Potential of Bifidobacterium and Lactobacillus against Species of Clostridium

1
Programa de Pós-graduação em Ciências da Saúde, Universidade Federal do Maranhão, Av. dos Portugueses, campus do Bacanga, São Luís 65065545, MA, Brazil
2
Programa de Pós-graduação, Universidade Ceuma, Rua dos Castanheiros No. 1, jardim Renascença II, São Luís 65075120, MA, Brazil
3
Departamento de Biologia, Universidade Federal do Maranhão, Av. dos Portugueses, campus do Bacanga, São Luís 65065545, MA, Brazil
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(2), 448; https://doi.org/10.3390/nu11020448
Received: 26 December 2018 / Revised: 11 February 2019 / Accepted: 18 February 2019 / Published: 21 February 2019
(This article belongs to the Special Issue Health Benefits of Traditional and Next Generation Probiotics)
Many Clostridium species are found as commensal members of the intestinal microbiota. However, imbalances of the microbiota may lead to certain infections caused by these microorganisms, mainly Clostridium butyricum, Clostridium difficile, and Clostridium perfringens. In many cases, infection recurrence can occur after antibiotics, indicating the need for novel therapeutic options that act on the pathogens and also restore the microbiota. Herein, the in vitro antimicrobial activity and probiotic potential of clinical and reference strains of Bifidobacterium and Lactobacillus were investigated against Clostridium species. Antimicrobial activity was evaluated by the agar spot test and inhibition of gas production. Then, the probiotic potential of selected strains was assessed by analyzing their coaggregation ability, adhesive properties to host cells and mucin, tolerance to acidic pH and bile salts, and antimicrobial susceptibility profiles. Lactobacillus plantarum ATCC 8014 was the most promising strain based on its inhibitory activity against Clostridium spp. Also, this strain met criteria to be considered a probiotic based on its coaggregation ability, adhesive properties, and tolerance to harsh pH and bile acid salt conditions. The results indicate that among the studied strains, L. plantarum ATCC 8014 presents probiotic potential for controlling infections induced by the studied Clostridium species and should be further evaluated in in vivo animal models. View Full-Text
Keywords: probiotics; Lactobacillus plantarum; Clostridium; dysbiosis; antimicrobial activity probiotics; Lactobacillus plantarum; Clostridium; dysbiosis; antimicrobial activity
Show Figures

Figure 1

MDPI and ACS Style

Monteiro, C.R.A.V.; do Carmo, M.S.; Melo, B.O.; Alves, M.S.; dos Santos, C.I.; Monteiro, S.G.; Bomfim, M.R.Q.; Fernandes, E.S.; Monteiro-Neto, V. In Vitro Antimicrobial Activity and Probiotic Potential of Bifidobacterium and Lactobacillus against Species of Clostridium. Nutrients 2019, 11, 448. https://doi.org/10.3390/nu11020448

AMA Style

Monteiro CRAV, do Carmo MS, Melo BO, Alves MS, dos Santos CI, Monteiro SG, Bomfim MRQ, Fernandes ES, Monteiro-Neto V. In Vitro Antimicrobial Activity and Probiotic Potential of Bifidobacterium and Lactobacillus against Species of Clostridium. Nutrients. 2019; 11(2):448. https://doi.org/10.3390/nu11020448

Chicago/Turabian Style

Monteiro, Cinara R.A.V.; do Carmo, Monique S.; Melo, Bruna O.; Alves, Matheus S.; dos Santos, Camilla I.; Monteiro, Sílvio G.; Bomfim, Maria R.Q.; Fernandes, Elizabeth S.; Monteiro-Neto, Valério. 2019. "In Vitro Antimicrobial Activity and Probiotic Potential of Bifidobacterium and Lactobacillus against Species of Clostridium" Nutrients 11, no. 2: 448. https://doi.org/10.3390/nu11020448

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop