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Tributyrin in Inflammation: Does White Adipose Tissue Affect Colorectal Cancer?

1
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo (USP), Av. Lineu Prestes, 1524-lab.435, 05508-000 São Paulo, SP, Brazil
2
Department of Physical Education, Exercise and Immunometabolism Research Group, Post-Graduation Program in Movement Sciences, Universidade Estadual Paulista (UNESP), Rua Roberto Simonsen, 305, 19060-900 Presidente Prudente, SP, Brazil
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(1), 110; https://doi.org/10.3390/nu11010110
Received: 27 November 2018 / Revised: 27 December 2018 / Accepted: 3 January 2019 / Published: 8 January 2019
(This article belongs to the Special Issue Nutrition and Colorectal Cancer)
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Abstract

Colorectal cancer affects the large intestine, leading to loss of white adipose tissue (WAT) and alterations in adipokine secretion. Lower incidence of colorectal cancer is associated with increased fibre intake. Fructooligosaccharides (FOS) are fibres that increase production of butyrate by the intestinal microbiota. Tributyrin, a prodrug of butyric acid, exerts beneficial anti-inflammatory effects on colorectal cancer. Our aim was to characterise the effects of diets rich in FOS and tributyrin within the context of a colon carcinogenesis model, and characterise possible support of tumorigenesis by WAT. C57/BL6 male mice were divided into four groups: a control group (CT) fed with chow diet and three colon carcinogenesis-induced groups fed either with chow diet (CA), tributyrin-supplemented diet (BUT), or with FOS-supplemented diet. Colon carcinogenesis decreased adipose mass in subcutaneous, epididymal, and retroperitoneal tissues, while also reducing serum glucose and leptin concentrations. However, it did not alter the concentrations of adiponectin, interleukin (IL)-6, IL-10, and tumour necrosis factor alpha (TNF)-α in WAT. Additionally, the supplements did not revert the colon cancer affected parameters. The BUT group exhibited even higher glucose tolerance and levels of IL-6, VEGF, and TNF-α in WAT. To conclude our study, FOS and butyrate supplements were not beneficial. In addition, butyrate worsened adipose tissue inflammation. View Full-Text
Keywords: colon carcinogenesis; butyrate; white adipose tissue; fructooligosaccharides colon carcinogenesis; butyrate; white adipose tissue; fructooligosaccharides
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Biondo, L.A.; Teixeira, A.A.S.; Silveira, L.S.; Souza, C.O.; Costa, R.G.F.; Diniz, T.A.; Mosele, F.C.; Rosa Neto, J.C. Tributyrin in Inflammation: Does White Adipose Tissue Affect Colorectal Cancer? Nutrients 2019, 11, 110.

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