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Fatty Acids and Calcium Regulation in Prostate Cancer

Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 955 Main Street, Buffalo, NY 14203, USA
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Nutrients 2018, 10(6), 788; https://doi.org/10.3390/nu10060788
Received: 15 May 2018 / Revised: 14 June 2018 / Accepted: 15 June 2018 / Published: 19 June 2018
(This article belongs to the Special Issue Calcium and Human Health)
Prostate cancer is a widespread malignancy characterized by a comparative ease of primary diagnosis and difficulty in choosing the individualized course of treatment. Management of prostate cancer would benefit from a clearer understanding of the molecular mechanisms behind the transition to the lethal, late-stage forms of the disease, which could potentially yield new biomarkers for differential prognosis and treatment prioritization in addition to possible new therapeutic targets. Epidemiological research has uncovered a significant correlation of prostate cancer incidence and progression with the intake (and often co-intake) of fatty acids and calcium. Additionally, there is evidence of the impact of these nutrients on intracellular signaling, including the mechanisms mediated by the calcium ion as a second messenger. The present review surveys the recent literature on the molecular mechanisms associated with the critical steps in the prostate cancer progression, with special attention paid to the regulation of these processes by fatty acids and calcium homeostasis. Testable hypotheses are put forward that integrate some of the recent results in a more unified picture of these phenomena at the interface of cell signaling and metabolism. View Full-Text
Keywords: androgen independence; bone; castration resistance; exosomes; hypoxia; metastasis; myosin IC; obesity androgen independence; bone; castration resistance; exosomes; hypoxia; metastasis; myosin IC; obesity
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Maly, I.V.; Hofmann, W.A. Fatty Acids and Calcium Regulation in Prostate Cancer. Nutrients 2018, 10, 788.

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