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Nutrients 2018, 10(5), 612; https://doi.org/10.3390/nu10050612

Association of Genetic Variation in the Epithelial Sodium Channel Gene with Urinary Sodium Excretion and Blood Pressure

1
Department of Foods and Nutrition, College of Natural Sciences, Dongduk Women’s University, Seoul 02748, Korea
2
Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul 04764, Korea
3
Nutrition and Diet Research Group, Korea Food Research Institute, Jeollabuk-do 55365, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 26 March 2018 / Revised: 10 May 2018 / Accepted: 11 May 2018 / Published: 14 May 2018
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Abstract

This study was performed to investigate whether genetic variation in the epithelial sodium channel (ENaC) is associated with 24-h urinary sodium excretion and blood pressure. A total of 3345 participants of the KoGES_Ansan and Ansung study were eligible for this study. Genomic DNA samples were isolated from peripheral blood and genotyped on the Affymetrix Genome-Wide Human SNP Array 5.0. Thirty-four single nucleotide polymorphisms (SNPs) were extracted for gene regions (SCNN1A, SCNN1B, and SCNN1G) as additive components by using Plink. Twenty-four-hour sodium excretions were estimated from spot urine samples using the Tanaka formula. The general linear model (GLM) was applied to assess the association between SNPs and urinary sodium excretion or blood pressure. In the SCNN1G gene, six SNPs (rs4073291, rs12934362, rs7404408, rs4494543, rs5735, and rs6497657) were significantly different in 24-h urinary sodium excretion according to gene variants. However, no difference was found in blood pressure among participants with gene variants of ENaC. Our finding indicated that 24-h urinary sodium excretions were different according to variants of the SCNN1G gene in large samples. Further studies to replicate these findings are warranted. View Full-Text
Keywords: ENaC; genetic variant; SCNN1A; SCNN1B; SCNN1G; blood pressure; 24-h urinary sodium excretion ENaC; genetic variant; SCNN1A; SCNN1B; SCNN1G; blood pressure; 24-h urinary sodium excretion
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Yang, Y.J.; Kim, J.; Kwock, C.K. Association of Genetic Variation in the Epithelial Sodium Channel Gene with Urinary Sodium Excretion and Blood Pressure. Nutrients 2018, 10, 612.

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