Protective Effects of Ellagitannin-Rich Strawberry Extracts on Biochemical and Metabolic Disturbances in Rats Fed a Diet High in Fructose
by
Bartosz Fotschki 1,*
, Jerzy Juśkiewicz 1,*, Krzysztof Kołodziejczyk 2, Adam Jurgoński 1, Monika Kosmala 2, Joanna Milala 2, Katarzyna Ognik 3 and Zenon Zduńczyk 1
Bartosz Fotschki 1,*, Jerzy Juśkiewicz 1,*, Krzysztof Kołodziejczyk 2, Adam Jurgoński 1, Monika Kosmala 2, Joanna Milala 2, Katarzyna Ognik 3 and Zenon Zduńczyk 1
1
Institute of Animal Reproduction and Food Research, Division of Food Science, Tuwima 10, 10-748 Olsztyn, Poland
2
Institute of Food Technology and Analysis, Lodz University of Technology, Stefanowskiego 4/10, 90-924 Lodz, Poland
3
Department of Biochemistry and Toxicology, Faculty of Biology, Animal Sciences and Bioeconomy, University of Life Sciences, 20-950 Lublin, Poland
*
Authors to whom correspondence should be addressed.
Nutrients 2018, 10(4), 445; https://doi.org/10.3390/nu10040445
Received: 12 March 2018 / Revised: 29 March 2018 / Accepted: 30 March 2018 / Published: 4 April 2018
(This article belongs to the Special Issue Phytochemicals in Health and Disease)
The present study compares the effects of two dietary strawberry extracts rich in monomeric (ME) or dimeric (DE) ellagitannins (ETs) on gastrointestinal, blood and tissue biomarkers in Wistar rats fed high-fructose diets. Both strawberry extracts beneficially affect the antioxidant status and lipid profile of the liver and serum. The ME extract shows a greater ability to inhibit lipid peroxidation in kidneys, more effectively decreases serum and liver triglycerides, and exerts greater anti-inflammatory effects in blood serum than the DE extract. The DE extract significantly reduces the activity of microbial enzymes in the cecum. These effects might be associated with higher cecum and urine levels of ET metabolites in rats fed with ME than in rats fed with DE. In conclusion, the diet-induced fructose-related disturbances observed in biochemical parameters are regulated by both extracts; nevertheless, the beneficial effects of the ME extract are mostly associated with systemic parameters, while those of the DE extracts are associated with local microbial activity.
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Keywords:
monomeric ellagitannins; nasutin A; microbiota activity; glutathione; inflammatory cytokines
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MDPI and ACS Style
Fotschki, B.; Juśkiewicz, J.; Kołodziejczyk, K.; Jurgoński, A.; Kosmala, M.; Milala, J.; Ognik, K.; Zduńczyk, Z. Protective Effects of Ellagitannin-Rich Strawberry Extracts on Biochemical and Metabolic Disturbances in Rats Fed a Diet High in Fructose. Nutrients 2018, 10, 445.
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