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Open AccessArticle

Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis

Liaoning Laboratory of Cancer Genetics and Epigenetics and Department of Cell Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China
Laboratory Animal Center, Dalian Medical University, Dalian 116044, China
Author to whom correspondence should be addressed.
Nutrients 2018, 10(3), 279;
Received: 7 January 2018 / Revised: 18 February 2018 / Accepted: 25 February 2018 / Published: 28 February 2018
Thyroid cancer (TC) is the most common endocrine malignancy without reliable preventive agent. Resveratrol possesses in vitro anti-TC activities; while its effect(s) on thyroid tumorigenesis remains unknown. This study aims to address this issue using DEN/MNU/DHPN-induced rat carcinogenesis model. 50 male Sprague-Dawley rats were separated into four groups as Group-1 (5 rats); normally fed; Group-2 (15 rats); DEN/MNU/DHPN treatment only; Group-3 (15 rats) and -4 (15 rats); DEN/MNU/DHPN treatment; followed by resveratrol intragastric (IG) injection and intraperitoneal (IP) injection; respectively; in two-day intervals for 30 weeks. The results revealed that the average resveratrol concentration in thyroid tissues was 1.278 ± 0.419 nmol/g in IG group and 1.752 ± 0.398 nmol/g in IP group. The final body weights of Group-3 and Group-4 were lighter than that (p > 0.05) of Group-1; but heavier than Group-2 (p < 0.05). TC-related lesions (hyperplasia and adenomas) were found in 53.3% of Group-2; 33.3% Group-3 and 26.7% Group-4. Lower serum carcino-embryonic antigen (CEA) and thyroglobulin (Tg) levels; down-regulated expression of IL-6 and cyclooxygenase-2 (COX-2); reduction of NF-κB/p65 nuclear translocation; and elevated IkBα expression were found in the thyroid tissues of Group-3 and Group-4 in comparison with that of Group-2. These results demonstrate that IG and IP administered resveratrol efficiently reduces the frequency and severity of DEN/MNU/DHPN-caused TC-related lesions and would be of values in thyroid tumor prevention. View Full-Text
Keywords: thyroid tumorigenesis; resveratrol; chemoprevention thyroid tumorigenesis; resveratrol; chemoprevention
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Zheng, X.; Jia, B.; Song, X.; Kong, Q.-Y.; Wu, M.-L.; Qiu, Z.-W.; Li, H.; Liu, J. Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis. Nutrients 2018, 10, 279.

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    Description: Figure S1 ELISA evaluation of serum Tg and CEA levels in the rats of the four experimental groups without and with pathological alterations in the liver, colon and lungs.
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