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Nutrients 2018, 10(12), 1972; https://doi.org/10.3390/nu10121972

Gender- and Age-Related Changes in Trunk Muscle Composition Using Chemical Shift Encoding-Based Water–Fat MRI

1
Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
2
Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
3
Institute of Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Georg-Brauchle-Ring 62, 80992 Munich, Germany
*
Author to whom correspondence should be addressed.
Received: 31 October 2018 / Revised: 27 November 2018 / Accepted: 11 December 2018 / Published: 13 December 2018
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Abstract

Ageing, sarcopenia, and malnutrition are associated with quantitative and qualitative changes of body composition. There are several imaging modalities, including magnetic resonance imaging (MRI), for the assessment of trunk muscle tissue composition. In this study, we investigated the gender- and age-related changes in trunk muscle composition using chemical shift encoding-based water–fat MRI. A total of 79 healthy volunteers (26 men: 38.9 ± 10.4 years; 53 women: 39.5 ± 15.0 years) underwent 3T axial MRI using a six-echo multi-echo 3D spoiled gradient echo sequence, allowing for the calculation of the proton density fat fraction (PDFF) in the trunk muscles. PDFF of the abdominal, psoas, and erector spinae muscles were determined. We detected significant positive correlations for abdominal muscle PDFF with age (r = 0.638, p = 0.0001) in men, and for abdominal muscle PDFF (r = 0.709, p = 0.0001) and erector spinae muscle PDFF (r = 0.674, p = 0.0001) with age in women. After adjustment for body mass index (BMI), only the correlation of age and abdominal muscle PDFF in women remained significant (r = 0.631, p = 0.0001). The findings of this study suggest that an increasing fat deposition in muscle is driven primarily by age, rather than BMI, in women. These results further support that PDFF can be considered a valid imaging biomarker of trunk muscle composition. View Full-Text
Keywords: skeletal muscle; magnetic resonance imaging; muscular fat deposition; obesity; BMI skeletal muscle; magnetic resonance imaging; muscular fat deposition; obesity; BMI
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Burian, E.; Syväri, J.; Holzapfel, C.; Drabsch, T.; Kirschke, J.S.; Rummeny, E.J.; Zimmer, C.; Hauner, H.; Karampinos, D.C.; Baum, T.; Franz, D. Gender- and Age-Related Changes in Trunk Muscle Composition Using Chemical Shift Encoding-Based Water–Fat MRI. Nutrients 2018, 10, 1972.

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