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Open AccessArticle

Low Salivary Amylase Gene (AMY1) Copy Number Is Associated with Obesity and Gut Prevotella Abundance in Mexican Children and Adults

1
Facultad de Química, Unidad de Genómica de Poblaciones Aplicada a la Salud, Universidad Nacional Autónoma de México (UNAM)/Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico
2
Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico City 03940, Mexico
3
Escuela Nacional de Antropología e Historia, Laboratorio de genética molecular, Mexico City 14030, Mexico
4
Departamento de Alergia e Inmunología Clínica, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico
5
Unidad Académica de Investigación Epidemiológica del Centro de Investigación en Políticas, Población y Salud, Facultad de Medicina-UNAM, Mexico City 04510, Mexico
6
Laboratorio de Genómica del Metabolismo Óseo, INMEGEN, Mexico City 14610, Mexico
7
Laboratorio de Enfermedades Cardiovasculares, INMEGEN, Mexico City 14610, Mexico
8
Unidad de Investigación en Enfermedades Metabólicas and Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14000, Mexico
9
Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo León 64710, Mexico
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(11), 1607; https://doi.org/10.3390/nu10111607
Received: 19 September 2018 / Revised: 20 October 2018 / Accepted: 23 October 2018 / Published: 1 November 2018
(This article belongs to the Special Issue Gut Microbiota and Obesity)
Genome-wide association studies (GWAS) have identified copy number variants (CNVs) associated with obesity in chromosomal regions 1p31.1, 10q11.22, 11q11, 16p12.3, and recently 1p21.1, which contains the salivary amylase gene (AMY1). Recent evidence suggests this enzyme may influence gut microbiota composition through carbohydrate (mainly starch) degradation. The role of these CNVs in obesity has been scarcely explored in the Latino population, and thus the aim of our study was to evaluate the association of 1p31.1, 10q11.22, 11q11, 16p12.3 and 1p21.1 CNVs with obesity in 921 Mexican children, to replicate significant associations in 920 Mexican adults, and to analyze the association of AMY1 copy number with gut microbiota in 75 children and 45 adults. Of the five CNVs analyzed, 1q11 CNV was significantly associated with obesity in children, but not in adults. Only AMY1 CNV was significantly associated with obesity in both age groups. Moreover, gut microbiota analyses revealed a positive correlation between AMY1 copy number and Prevotella abundance. This genus has enzymes and gene clusters essential for complex polysaccharide degradation and utilization. To our knowledge, this is the first study to analyze the association of these five CNVs in the Mexican population and to report a correlation between AMY1 CN and gut microbiota in humans. View Full-Text
Keywords: CNVs; obesity; Mexican; AMY1; Prevotella CNVs; obesity; Mexican; AMY1; Prevotella
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León-Mimila, P.; Villamil-Ramírez, H.; López-Contreras, B.E.; Morán-Ramos, S.; Macias-Kauffer, L.R.; Acuña-Alonzo, V.; Del Río-Navarro, B.E.; Salmerón, J.; Velazquez-Cruz, R.; Villarreal-Molina, T.; Aguilar-Salinas, C.A.; Canizales-Quinteros, S. Low Salivary Amylase Gene (AMY1) Copy Number Is Associated with Obesity and Gut Prevotella Abundance in Mexican Children and Adults. Nutrients 2018, 10, 1607.

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