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Nutrients 2018, 10(1), 59; https://doi.org/10.3390/nu10010059

Is Hypovitaminosis D Related to Incidence of Type 2 Diabetes and High Fasting Glucose Level in Healthy Subjects: A Systematic Review and Meta-Analysis of Observational Studies

Department of Clinical medicine, Aarhus University Hospital , Aarhus University, Tage-Hansen’s Gade 2, 8000 Aarhus C, Denmark
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Received: 9 December 2017 / Revised: 21 December 2017 / Accepted: 28 December 2017 / Published: 10 January 2018
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Abstract

There is evidence that vitamin D status is associated with type 2 diabetes. Many observational studies have been performed investigating the relationship of vitamin D status and circulating biomarkers of glycemic regulation. To find out whether this association holds, we conducted a systematic review and meta-analysis of cross sectional and longitudinal studies. We searched Pubmed, Medline and Embase, all through June 2017. The studies were selected to determine the effect of vitamin D on the parameters of glucose metabolism in diabetic and non-diabetic subjects. Correlation coefficients from all studies were pooled in a random effects meta-analysis. The risk of bias was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. We found significant inverse relationship of vitamin D status with glycemic level in both diabetic (r = −0.223, 95% CI = −0.184 to −0.261, p = 0.000) and non-diabetic (r = −0.073, 95% CI = −0.052 to −0.093, p = 0.000) subjects. This meta-analysis concludes that hypovitaminosis D is associated with increased risk of hyperglycemia both in diabetic and non-diabetic subjects. A future strategy for the prevention of impaired glycemic regulation could be individualized supplementation of vitamin D. View Full-Text
Keywords: 25 (OH) vitamin D; Vitamin D; Type 2 diabetes; hyperglycemia; meta-analysis 25 (OH) vitamin D; Vitamin D; Type 2 diabetes; hyperglycemia; meta-analysis
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Rafiq, S.; Jeppesen, P.B. Is Hypovitaminosis D Related to Incidence of Type 2 Diabetes and High Fasting Glucose Level in Healthy Subjects: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients 2018, 10, 59.

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