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Open AccessArticle

Benefits of Fish Oil Consumption over Other Sources of Lipids on Metabolic Parameters in Obese Rats

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Department of Veterinary Medicine, Federal University of Lavras (UFLA), Minas Gerais 37200-000, Brazil
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Department of Animal Sciences, Federal University of Lavras (UFLA), Minas Gerais 37200-000, Brazil
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Department of Health Sciences, Federal University of Lavras (UFLA), Minas Gerais 37200-000, Brazil
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Author to whom correspondence should be addressed.
Nutrients 2018, 10(1), 65; https://doi.org/10.3390/nu10010065
Received: 6 November 2017 / Revised: 15 December 2017 / Accepted: 22 December 2017 / Published: 10 January 2018
This study evaluated the effect of the consumption of different levels and sources of lipids on metabolic parameters of Wistar rats. Animals were fed with high-fat diet (HFD) containing 20% of lard for 12 weeks to cause metabolic obesity. Subsequently, the animals were divided into six groups and were fed diets with lipid concentrations of 5% or 20% of lard (LD), soybean oil (SO) or fish oil (FO), for 4 weeks. Data were submitted to analysis of variance (two-way) followed by Tukey post hoc test (p < 0.05). The groups that consumed FO showed less weight gain and lower serum levels of triacylglycerol (TAG), total cholesterol and fractions, aspartate aminotransferase (AST) activity, atherogenic index, less amount of fat in the carcass, decreased Lee index and lower total leukocyte counting (p < 0.05). These same parameters were higher in LD treatment (p < 0.05). In the concentration of 20%, carcass fat content, blood glucose levels, as well as alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) decreased in FO groups (p < 0.05). The SO group had intermediate results regarding the other two treatments (FO and LD). We concluded that fish oil intake was able to modulate positively the metabolic changes resulting from HFD. View Full-Text
Keywords: polyunsaturated fatty acids (PUFA); plasma lipids; dietary fat; n-3 fatty acids; metabolic syndrome; n-6 fatty acids; saturated fatty acids polyunsaturated fatty acids (PUFA); plasma lipids; dietary fat; n-3 fatty acids; metabolic syndrome; n-6 fatty acids; saturated fatty acids
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Gondim, P.N.; Rosa, P.V.; Okamura, D.; Silva, V.D.O.; Andrade, E.F.; Biihrer, D.A.; Pereira, L.J. Benefits of Fish Oil Consumption over Other Sources of Lipids on Metabolic Parameters in Obese Rats. Nutrients 2018, 10, 65.

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