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Clinics and Practice, Volume 15, Issue 3

2025 March - 28 articles

Cover Story: Traumatic brain injury (TBI) often occurs in the setting of polytrauma, and critical care treatment of TBI must take co-morbidities of TBI that are caused by trauma into account. Comorbidities can include traumatic injury to many other body systems. However, in addition to co-morbid injuries, TBI itself can independently lead to both acute and chronic dysfunction in other organs or parts of the body, with extracranial effects being observed in cardiovascular, pulmonary, renal, gastrointestinal, hormonal, hemostatic, and immune systems, among others. An understanding of such effects is critical to best practice in the treatment of acute and chronic TBI, and to the routine health maintenance care of patients with chronic TBI. View this paper
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Articles (28)

  • Review
  • Open Access
7 Citations
4,407 Views
13 Pages

Enhancing Smile Aesthetics and Function with Lithium Disilicate Veneers: A Brief Review and Case Study

  • Jose Villalobos-Tinoco,
  • Franciele Floriani,
  • Silvia Rojas-Rueda,
  • Salwa Mekled,
  • Clint Conner,
  • Staley Colvert and
  • Carlos A. Jurado

Background: Lithium disilicate ceramic veneers are considered the gold standard in aesthetic dentistry due to their translucency, strength, and adhesive bonding properties. This clinical case report details the aesthetic rehabilitation of a patient t...

  • Review
  • Open Access
6 Citations
4,311 Views
37 Pages

Alpha-synuclein has been associated with neurodegeneration, especially in Parkinson’s disease (PD). This study aimed to review clinical, biochemical, and neuroimaging markers and management of prodromal synucleinopathies. The prodromal state of...

  • Article
  • Open Access
3 Citations
2,950 Views
17 Pages

Evaluation of the Effects of Photobiomodulation on Bone Density After Placing Dental Implants: A Pilot Study Using Cone Beam CT Analysis

  • Ruxandra-Elena Luca,
  • Alessandro Del Vecchio,
  • Ioana-Roxana Munteanu,
  • Mădălin-Marius Margan and
  • Carmen Darinca Todea

Background: One of the parameters of maximum interest regarding the quality of the intraoral hard tissues is represented by the bone density, with direct clinical implications. The evaluation of this extremely important clinical parameter can be achi...

  • Article
  • Open Access
2,488 Views
16 Pages

Background: Although previous studies have suggested a variety of sociodemographic and psychological factors as predictors of poor outcomes in patients with chronic low back pain (CLBP), longitudinal studies remain rare. Objectives: To examine the pr...

  • Review
  • Open Access
11 Citations
1,822 Views
17 Pages

Efficiency and Applicability of Virtual Surgical Planning in Maxillofacial and Mandibular Bone Reconstruction: A Narrative Review

  • Mohammed Mahmoud Shalabi,
  • Khaldoun M. A. Darwich,
  • Mohammad Naem Kheshfeh and
  • Mohammad Younis Hajeer

Background: Facial structures are critical to aesthetics and function. Deformities can cause significant problems. Advances in surgical techniques, including three-dimensional (3D) computer simulation and virtual surgical planning (VSP), have improve...

  • Systematic Review
  • Open Access
3 Citations
3,566 Views
16 Pages

Acute Appendicitis or Appendiceal Diverticulitis? A Case Report and Systematic Literature Review

  • Stipe Vidović,
  • Nenad Čekić,
  • Ivica Šuvak,
  • Mladen Ugljarević and
  • Zenon Pogorelić

Background: Appendiceal diverticulitis is a rare and poorly understood condition of the appendix. The diagnosis of appendiceal diverticulitis is challenging due to its rarity and a clinical presentation that often mimics other ileocecal disorders. Un...

  • Article
  • Open Access
1 Citations
1,130 Views
14 Pages

Background: Dysphagia is a common complication in myopathy, significantly impacting patients’ quality of life (QoL) and overall health. Caregivers play a critical role in identifying and addressing swallowing difficulties in this population. Th...

  • Systematic Review
  • Open Access
6 Citations
3,011 Views
13 Pages

Triggers, Types, and Treatments for Kounis Syndrome: A Systematic Review

  • Erick Rochel-Perez,
  • Miguel Santaularia-Tomas,
  • Mario Martin-Dorantes,
  • Edgar Villareal-Jimenez,
  • Amonario Olivera-Mar,
  • Ely Sanchez-Felix,
  • Adrian Perez-Navarrete,
  • Jose Luis Millet-Herrera,
  • Osvaldo Huchim-Mendez and
  • Nina Mendez-Dominguez
  • + 1 author

Background: Kounis syndrome (KS), also known as allergic myocardial infarction, presents in three variants. This condition is often underrecognized due to limited knowledge and its variable presentation. To address these limitations, the present revi...

  • Article
  • Open Access
2 Citations
1,304 Views
14 Pages

Background: This study evaluates changes in the foveal avascular zone (FAZ) area and vessel density in patients with full-thickness macular hole (FTMH) before and after vitrectomy using optical coherence tomography–angiography (OCT-A). Methods:...

  • Systematic Review
  • Open Access
3 Citations
4,512 Views
13 Pages

Pyoderma Gangrenosum in a Patient with Crohn’s Disease Treated with Adalimumab: A Case-Based Review and Systematic Review of the Current Literature

  • Fotios S. Fousekis,
  • Konstantinos Mpakogiannis,
  • Emmanouil Karampinis,
  • Ioanna Nefeli Mastorogianni,
  • Dimitrios K. Christodoulou,
  • Marina Papoutsaki,
  • Evanthia Zampeli and
  • Konstantinos H. Katsanos

Background: Pyoderma gangrenosum (PG) is a rare inflammatory cutaneous disorder that frequently occurs in association with systemic diseases such as inflammatory bowel disease (IBD). This case report describes a 23-year-old female with Crohn’s...

  • Article
  • Open Access
30 Citations
4,571 Views
12 Pages

Exploring the Role of Guilt in Eating Disorders: A Pilot Study

  • Fabiola Raffone,
  • Danilo Atripaldi,
  • Eugenia Barone,
  • Luigi Marone,
  • Marco Carfagno,
  • Francesco Mancini,
  • Angelo Maria Saliani and
  • Vassilis Martiadis

Background/Objectives: Eating disorders (EDs) are complex psychopathological conditions involving dysfunctional eating behaviors, excessive body image concerns, and impaired emotional regulation. Among moral emotions, guilt plays a significant role i...

  • Case Report
  • Open Access
2 Citations
4,718 Views
11 Pages

Two Long-Acting Antipsychotics in a Patient with Treatment-Resistant Schizophrenia: A Case Report

  • Salvatore Cipolla,
  • Flora Delli Carpini,
  • Pierluigi Catapano,
  • Valeria De Santis,
  • Antonio Volpicelli,
  • Francesco Perris and
  • Francesco Catapano

Treatment-resistant schizophrenia (TRS) poses significant therapeutic challenges due to persistent symptoms, poor adherence, and high relapse rates. Long-acting injectable (LAI) antipsychotics offer a promising approach, yet limited evidence exists r...

  • Review
  • Open Access
13 Citations
13,764 Views
19 Pages

High Polyphenol Extra Virgin Olive Oil and Metabolically Unhealthy Obesity: A Scoping Review of Preclinical Data and Clinical Trials

  • Konstantina Liva,
  • Athanasios A. Panagiotopoulos,
  • Alexandra Foscolou,
  • Charalampia Amerikanou,
  • Alkistis Vitali,
  • Stavros Zioulis,
  • Konstantina Argyri,
  • Georgios I. Panoutsopoulos,
  • Andriana C. Kaliora and
  • Aristea Gioxari

Background/Objectives: During the last decade, there has been an increased interest in phenolic compound-rich natural products as natural therapies for regulating the molecular pathways behind central obesity and associated metabolic disorders. The p...

  • Protocol
  • Open Access
1 Citations
1,527 Views
12 Pages

Background: We aim to evaluate the effect of the Nordic Walking program on the quality of life and functionality of individuals with intellectual disabilities; Methods: The NORDIN-JOY study is designed as a multicenter, randomized crossover trial. Pa...

  • Systematic Review
  • Open Access
3 Citations
1,800 Views
45 Pages

Insurance Payor Status and Outcomes in Pediatric Sports-Related Injuries: A Rapid Review

  • Katherine M. Kutzer,
  • Lulla V. Kiwinda,
  • Daniel Yang,
  • John Kyle Mitchell,
  • Emily J. Luo,
  • Emily J. Harman,
  • Stephanie Hendren,
  • Kendall E. Bradley and
  • Brian C. Lau

Introduction: The rise in youth sports participation has led to an increase in pediatric sports-related injuries in the United States, contributing to growing healthcare costs and exacerbating socioeconomic disparities. Insurance payor status is a cr...

  • Systematic Review
  • Open Access
3 Citations
3,669 Views
17 Pages

Clinical Efficacy of Prolotherapy for Temporomandibular Joint Disorders: A Systematic Review and Meta-Analysis

  • Antonios Saramantos,
  • Athanassios Kyrgidis,
  • Gregorios Venetis,
  • Georgios Hatziantoniou,
  • Anestis Chrysostomidis,
  • Chrysanthi Sardeli and
  • Ioannis Tilaveridis

Background: Temporomandibular disorders (TMDs) encompass a group of conditions characterized by anatomical, histological, and/or functional abnormalities that affect the muscular and/or articular components of the temporomandibular joint. Prolotherap...

  • Article
  • Open Access
1 Citations
1,012 Views
12 Pages

Investigation of Electroencephalographic Aspects, Adaptive Features, and Clinical Phenotypes in a Group of Children with Autism—A Pilot Study

  • Alexandru Capisizu,
  • Leon Zăgrean,
  • Elena Poenaru,
  • Elena Tudorache,
  • Mihaela Anca Bulf and
  • Adriana Sorina Capisizu

(1) Background: Autism, as an important global problem that affects many phenotypically different individuals, is associated with electroencephalographic (EEG) abnormalities and adaptability impairment. (2) Materials and Methods: In this retrospectiv...

  • Case Report
  • Open Access
1 Citations
1,566 Views
11 Pages

Metastasis of Squamous Cell Carcinoma of the Larynx to the Right Adrenal Gland—A Case Report

  • Eliza Działach,
  • Michał Simlot,
  • Karolina Osowiecka,
  • Elżbieta Nowara,
  • Jarosław Markowski and
  • Mateusz Grajek

Background/Objectives: Malignant adrenal tumors comprise both primary adrenal neoplasms and metastatic lesions, with the latter being significantly more common. Squamous cell carcinoma (SCC) of the larynx is a prevalent head and neck cancer that typi...

  • Systematic Review
  • Open Access
5 Citations
4,296 Views
14 Pages

Dupilumab, a Potential Novel Treatment for Hailey–Hailey Disease

  • Liliana Gabriela Popa,
  • Calin Giurcaneanu,
  • Florentina Zaharia,
  • Andreea Grigoras,
  • Alexandra Denisa Oprea and
  • Cristina Beiu

Background/Objectives: Hailey–Hailey disease (HHD) is an uncommon genodermatosis with autosomal dominant inheritance caused by loss-of-function mutations in the ATP2C1 gene, which lead to disruption in keratinocyte adhesion and intraepidermal a...

  • Review
  • Open Access
3 Citations
5,353 Views
16 Pages

Extracranial Effects of Traumatic Brain Injury: A Narrative Review

  • Nathan K. Evanson,
  • Pratyusha Veldhi,
  • Caitlyn Scherpenberg,
  • John M. Riccobono,
  • Haitham Eid and
  • Jennifer L. McGuire

Background: Traumatic brain injury (TBI) is often associated with other injuries and comorbidities. However, even isolated TBI directly leads to dysfunction in multiple body systems outside the central nervous system. These extracranial effects of TB...

  • Article
  • Open Access
1 Citations
1,937 Views
14 Pages

Assessing Paramedics’ Competence and Training in End-of-Life Care: A Cross-Sectional Study in Saudi Arabia

  • Ahmed Alanazy,
  • Fatimah Khalifah Alsahli,
  • Zahra Essam Alhassan,
  • Zahra Hassan Alabdrabulridha,
  • Moneerah Khalifah Aljomaan and
  • Abdullah Alruwaili

Background: End-of-life (EOL) care is an integral part of paramedic services, requiring not only medical expertise but also communication skills and emotional support. With the evolving role of paramedics in providing palliative care, understanding t...

  • Article
  • Open Access
1,349 Views
14 Pages

Self-Reported Physical Activity Behavior and Practice of Healthcare Professionals During the Second and Third Trimester of Pregnancy in Greece

  • Vasileios Daglas,
  • Nikolaos Kostopoulos,
  • Michalis Mitrotasios,
  • Antigoni Sarantaki,
  • Maria Iliadou,
  • Athanasios Moustogiannis,
  • Maria Dagla and
  • Evangelia Antoniou

Background/Objectives: The primary aim of the study was to investigate the self-reported behavior and practice of healthcare professionals (midwives and obstetricians) regarding physical activity during the second and third trimesters of pregnancy. T...

  • Review
  • Open Access
5 Citations
5,213 Views
19 Pages

Mental Health and Malocclusion: A Comprehensive Review

  • Osama A. Alsulaiman,
  • Maha I. Alghannam,
  • Dalal M. Almazroua,
  • Abdulaziz S. Alamri,
  • Suliman Y. Shahin,
  • Essam A. Nassar,
  • Naif N. Almasoud,
  • Abdulrahman T. Alsulaiman and
  • Ahmed A. Alsulaiman

The purpose of this study is to comprehensively review the relationship between malocclusion and anxiety and depression. While the physical implications of malocclusion are well documented, recent scholarship has shifted focus to examining the direct...

  • Article
  • Open Access
2,518 Views
13 Pages

Background: Little is known about mental health among tuberculosis (TB) patients in Thailand. This study aimed to identify factors associated with mental health problems in TB patients in urban Thailand. Methods: This cross-sectional study collected...

  • Article
  • Open Access
2 Citations
3,315 Views
15 Pages

A Retrospective Study on the Incidence of Periprosthetic Fractures Related to Total Hip Arthroplasty and Postoperative Complications During Hospitalization

  • Victor Niculescu,
  • Delia Carmen Nistor-Cseppento,
  • Sebastian Tirla,
  • Brigitte Osser,
  • Cristina Aur,
  • Diana Mocuta,
  • Gheorghe Ion Popescu and
  • Radu Dan Necula

Background/Objectives: Periprosthetic fractures (PFs) are serious complications that can occur after total hip arthroplasty (THA), particularly in elderly patients who often have multiple comorbidities and low bone density. The surgical treatment of...

  • Article
  • Open Access
1,819 Views
20 Pages

Effects of a Multimodal Program on Frailty Syndrome and Psychological Alterations in Breast Cancer Women Treated with Aromatase Inhibitors

  • Pedro Céspedes,
  • Francisco M. Martínez-Arnau,
  • María Dolores Torregrosa,
  • Omar Cauli and
  • Cristina Buigues

Background/Objectives: Treatment with aromatase inhibitors can worsen frailty syndrome and psychological symptoms in women diagnosed with breast cancer (BC) receiving these drugs to prevent cancer recurrence. We analyze whether postmenopausal women w...

  • Study Protocol
  • Open Access
3 Citations
1,466 Views
10 Pages

Evaluation of Reminder App for Optimization of Bladder Filling Status During Hypo-Fractionated Irradiation for Prostate Cancer: Protocol of REFILL-PAC-HYPO Trial

  • Dirk Rades,
  • Jan-Dirk Küter,
  • Michael von Staden,
  • Ahmed Al-Salool,
  • Christian Ziemann,
  • Stefan Janssen,
  • Julia Koeck,
  • Justus Domschikowski,
  • Charlotte Kristiansen and
  • Florian Cremers
  • + 4 authors

Background/Objectives: During radiotherapy for prostate cancer, the risk of radiation cystitis is increased if the volume of the bladder is small. According to previous studies, it is important that bladder volumes are ≥200 mL. Drinking protocols...

  • Case Report
  • Open Access
1 Citations
1,249 Views
7 Pages

Surgical Treatment of Cranial Fasciitis in an Atypical Maxillary Region of a Pediatric Patient: A Case Report

  • Jetsi Marlen González-Fuentes,
  • Miguel Angel Noyola-Frías,
  • Oscar Arturo Benítez-Cárdenas,
  • Elhi Manuel Torres-Hernández,
  • Jessika Arlina González-Macías,
  • Andreu Comas-García,
  • Ricardo Martínez-Rider and
  • Marlen Vitales-Noyola

Objective: The aim of this case report is to show the surgical treatment of cranial fasciitis in a 2-year-old patient. Cranial fasciitis is an uncommon, nonmalignant, and swiftly proliferating lesion that primarily involves the cranium, predominantly...

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Clin. Pract. - ISSN 2039-7283