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Clinics and Practice
Special Issues
The Effect of Dietary Compounds on Inflammation-Mediated Diseases
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The Effect of Dietary Compounds on Inflammation-Mediated Diseases

A special issue of Clinics and Practice (ISSN 2039-7283).

Deadline for manuscript submissions: 20 September 2025 | Viewed by 1028

Special Issue Editors

Dr. Charalampia Amerikanou

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Guest Editor
Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece
Interests: chronic inflammation; molecular nutrition; nutritional immunology; functional foods
Special Issues, Collections and Topics in MDPI journals
Dr. Efstathia Papada

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Guest Editor
UCL Division of Medicine, University College London, UK
Interests: diet; gut health; natural products; phytochemicals; inflammation; inflammatory bowel disease; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Dr. Aristea Gioxari

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Guest Editor
Department of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, 70 El. Venizelou Avenue, 17671 Athens, Greece
Interests: randomized controlled clinical trials; human bioavailability studies; as well as studies on experimental models and cell culture lines; biochemical and biological processes of natural products and bioactive compounds in health and disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diet has been identified as a key modulator of inflammation. Chronic low-grade inflammation has been linked with the pathogenesis and progression of several non-communicable diseases, such as autoimmune, cardiovascular, neurodegenerative diseases, and even cancer. Several dietary compounds have been shown to possess either proinflammatory or anti-inflammatory properties. For example, saturated fat and refined carbohydrates may induce inflammatory and oxidative stress, and several micronutrients, such as minerals and vitamins, are known for their antiinflammatory potential. Not only nutrients, but also non nutrient microconstituents, such as phytochemicals, are important immunity and inflammatory modulators. The aim of this Special Issue is to welcome original clinical research and reviews on the investigation of the effect of specific foods or dietary compounds on inflammation-mediated diseases.

Dr. Charalampia Amerikanou
Dr. Efstathia Papada
Dr. Aristea Gioxari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Clinics and Practice is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diet
  • inflammation
  • oxidative stress
  • non-communicable diseases
  • micronutrients
  • macronutrients
  • bioactive com-pounds

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Published Papers (1 paper)

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Review

19 pages, 1090 KiB  
Review
High Polyphenol Extra Virgin Olive Oil and Metabolically Unhealthy Obesity: A Scoping Review of Preclinical Data and Clinical Trials
by Konstantina Liva, Athanasios A. Panagiotopoulos, Alexandra Foscolou, Charalampia Amerikanou, Alkistis Vitali, Stavros Zioulis, Konstantina Argyri, Georgios I. Panoutsopoulos, Andriana C. Kaliora and Aristea Gioxari
Clin. Pract. 2025, 15(3), 54; https://doi.org/10.3390/clinpract15030054 - 7 Mar 2025
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Abstract
Background/Objectives: During the last decade, there has been an increased interest in phenolic compound-rich natural products as natural therapies for regulating the molecular pathways behind central obesity and associated metabolic disorders. The present scoping review presents the outcomes of clinical and preclinical [...] Read more.
Background/Objectives: During the last decade, there has been an increased interest in phenolic compound-rich natural products as natural therapies for regulating the molecular pathways behind central obesity and associated metabolic disorders. The present scoping review presents the outcomes of clinical and preclinical studies examining the anti-obesity effects of high phenolic extra virgin olive oil (HP-EVOO) and its possible underlying molecular mechanisms. Methods: Studies published between 2014 and 2024 were searched via MEDLINE, Scopus, Cochrane, the Web of Science, Semantic Scholar, Google Scholar, Science.gov, and Clinicaltrials.gov databases. A combination of keywords and Boolean logic was used to search throughout the last decade in all databases, including “hyperglycemia” or “hypertension” or “metabolic syndrome” or “dyslipidemia” or “hyperlipidemia” or “hypoglycemia” or “obesity” or “macrovascular diabetic complications” or “microvascular diabetic complications” or “cardiovascular disease” or “overweight” or “insulin sensitivity” or “insulin resistance” and “extra virgin olive oil” or “high phenolic olive oil” and “human” or “animal model”. Results: The 10-year literature survey identified 21 studies in both animal models and humans, indicating that HP-EVOO improves inflammation, glycemic control, oxidative stress and endothelial function, potentially protecting against metabolic syndrome, hypertension and type 2 diabetes, even compared to EVOO. Moreover, HP-EVOO’s antiplatelet effect and improvement in HDL functionality reduce cardiovascular risk. Conclusions: The evidence presented in this study demonstrates that HP-EVOO represents an effective preventive and therapeutic dietary approach to cardiometabolic diseases. Full article
(This article belongs to the Special Issue The Effect of Dietary Compounds on Inflammation-Mediated Diseases)
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