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Case Report

Hepatosplenic Gamma-Delta T-Cell Lymphoma in a Female Patient after Delivery

by
Marjana Glaser
1,*,
Aleš Goropevšek
2,
Rajko Kavalar
3 and
Andrej Glaser
4
1
Department of Hematology and Hematological Oncology, Clinical Division of Internal Medicine, University Medical Centre Maribor, Ljubljanska Ulica 5, SI-2000 Maribor, Slovenia
2
Department of Laboratory Diagnosis, University Medical Centre Maribor, Ljubljanska Ulica 5, SI-2000 Maribor, Slovenia
3
Department of Pathology, University Medical Centre Maribor, Ljubljanska Ulica 5, SI-2000 Maribor, Slovenia
4
Faculty of Medicine, University Medical Centre Maribor, Ljubljanska Ulica 5, SI-2000 Maribor, Slovenia
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2012, 4(1), e4; https://doi.org/10.4081/hr.2012.e4
Submission received: 16 October 2011 / Revised: 9 January 2012 / Accepted: 9 January 2012 / Published: 28 February 2012

Abstract

Hepatosplenic γδ T-cell lymphoma (HSTCL) is a very rare peripheral T-cell lymphoma characterized by extranodal infiltration of mature malignant post-thymic T-lymphocytes into sinusoids of the liver and spleen without lymphadenopathy and significant cytopenias. The aetiology of the disease is unknown. We describe the case of a female patient in whom HSTCL developed after delivery and who was previously without disease. Flow cytometry and liver puncture are essential for diagnosing HSTCL, especially in patients with unexplained pancytopenia and hepatosplenomegaly. Since phenotypic results can easily be misinterpreted as non-malignant, the examiner should have enough experience to recognize clonal changes of T-lymphocytes. Namely, in contrast to B-lymphocytes, T-lymphocytes do not have an efficient indicator of clonality and are recognized by flow cytometry based only on aberrant expression of commonly present antigens of T-cell and NK-cell subsets. At present, there is no known cure for HSTCL with a maximum survival up to 2 years.
Keywords: T-cell hepatosplenic gamma-delta lymphoma; flow cytometry; γδ T- lymphocytes; delivery T-cell hepatosplenic gamma-delta lymphoma; flow cytometry; γδ T- lymphocytes; delivery

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MDPI and ACS Style

Glaser, M.; Goropevšek, A.; Kavalar, R.; Glaser, A. Hepatosplenic Gamma-Delta T-Cell Lymphoma in a Female Patient after Delivery. Hematol. Rep. 2012, 4, e4. https://doi.org/10.4081/hr.2012.e4

AMA Style

Glaser M, Goropevšek A, Kavalar R, Glaser A. Hepatosplenic Gamma-Delta T-Cell Lymphoma in a Female Patient after Delivery. Hematology Reports. 2012; 4(1):e4. https://doi.org/10.4081/hr.2012.e4

Chicago/Turabian Style

Glaser, Marjana, Aleš Goropevšek, Rajko Kavalar, and Andrej Glaser. 2012. "Hepatosplenic Gamma-Delta T-Cell Lymphoma in a Female Patient after Delivery" Hematology Reports 4, no. 1: e4. https://doi.org/10.4081/hr.2012.e4

APA Style

Glaser, M., Goropevšek, A., Kavalar, R., & Glaser, A. (2012). Hepatosplenic Gamma-Delta T-Cell Lymphoma in a Female Patient after Delivery. Hematology Reports, 4(1), e4. https://doi.org/10.4081/hr.2012.e4

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