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Hematology Reports
Volume 13
Issue 4
10.4081/hr.2021.8904
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Impact of Pharmacokinetics to Reduce Bleeding in a Cohort of Patients with Severe Hemophilia A in a Personalized Comprehensive Management Program

by
Samuel Sarmiento Doncel
1,*,
Gina Alejandra Diaz Mosquera
2,
Javier Mauricio Cortes
2,
Nelson Ramirez Plazas
3,
Francisco Javier Meza
4 and
Carol Agudelo Rico
1
1
Integral Solutions Research, Cra 7#, Bogotà 156-68, Colombia
2
Integral Solutions SD, Bogotà, Colombia
3
Hospital Universitario Hernando Moncaleano Perdomo, Neiva, Colombia
4
Hospital San Jorge, Pereira, Colombia
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2021, 13(4), 8904; https://doi.org/10.4081/hr.2021.8904
Submission received: 14 September 2020 / Revised: 22 April 2021 / Accepted: 17 September 2021 / Published: 26 November 2021

Abstract

In recent decades, hemophilia A treatment has been focused on body weight, without taking pharmacokinetic parameters into account. Previous research has shown that the individual pharmacokinetic response is more effective in predicting the required dose of clotting factor. We want to evaluate the impact on reducing the frequency of bleeding in patients treated with recombinant factor VIII, based on a personalized comprehensive management program. Our aim was to compare the results of a standard comprehensive treatment program (stage I) vs. a personalized pharmacokinetic-based treatment program (stage II) in a cohort of 60 patients with severe hemophilia without inhibitors. The median age was 15.5 years (3–68). The ABR was 1.03 (62 episodes) in the first stage and 0.58 (35 episodes) in the second one, (p = 0.004). By type of bleeding, the impact of the intervention differs significantly in spontaneous bleeding (p = 0.007) and a 73% reduction in the first stage. There were no significant differences in traumatic bleeding. The use of pharmacokinetics for personalized dosing of patients with severe hemophilia A, significantly reduces ABR and spontaneous bleeding, improving the patient's quality of life and costs for the health system.
Keywords: hemophilia A; bleeding; individualized treatment; recombinant factor VIII; ABR (annual bleeding rate) hemophilia A; bleeding; individualized treatment; recombinant factor VIII; ABR (annual bleeding rate)

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MDPI and ACS Style

Sarmiento Doncel, S.; Diaz Mosquera, G.A.; Cortes, J.M.; Ramirez Plazas, N.; Meza, F.J.; Agudelo Rico, C. Impact of Pharmacokinetics to Reduce Bleeding in a Cohort of Patients with Severe Hemophilia A in a Personalized Comprehensive Management Program. Hematol. Rep. 2021, 13, 8904. https://doi.org/10.4081/hr.2021.8904

AMA Style

Sarmiento Doncel S, Diaz Mosquera GA, Cortes JM, Ramirez Plazas N, Meza FJ, Agudelo Rico C. Impact of Pharmacokinetics to Reduce Bleeding in a Cohort of Patients with Severe Hemophilia A in a Personalized Comprehensive Management Program. Hematology Reports. 2021; 13(4):8904. https://doi.org/10.4081/hr.2021.8904

Chicago/Turabian Style

Sarmiento Doncel, Samuel, Gina Alejandra Diaz Mosquera, Javier Mauricio Cortes, Nelson Ramirez Plazas, Francisco Javier Meza, and Carol Agudelo Rico. 2021. "Impact of Pharmacokinetics to Reduce Bleeding in a Cohort of Patients with Severe Hemophilia A in a Personalized Comprehensive Management Program" Hematology Reports 13, no. 4: 8904. https://doi.org/10.4081/hr.2021.8904

APA Style

Sarmiento Doncel, S., Diaz Mosquera, G. A., Cortes, J. M., Ramirez Plazas, N., Meza, F. J., & Agudelo Rico, C. (2021). Impact of Pharmacokinetics to Reduce Bleeding in a Cohort of Patients with Severe Hemophilia A in a Personalized Comprehensive Management Program. Hematology Reports, 13(4), 8904. https://doi.org/10.4081/hr.2021.8904

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