Next Article in Journal
Transfusion-Associated Graftversus-Host Disease: A Brief Comment on Blood Safety
Previous Article in Journal
The Correlation between Hemostatic Parameters and Mortality Rate in Patients with Non-Small Cell Lung Cancer
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Hematology Reports
Volume 13
Issue 3
10.4081/hr.2021.9177
hematolrep-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

COVID-19 and Blood Groups: A Six-Months Observational Study in Ferrara, Italy

by
Salvatore Greco
1,
Nicolò Fabbri
2,
Alessandro Bella
1,
Beatrice Bonsi
1,
Alessandra Violi
1,
Valeria Fortunato
1,
Maurizio Govoni
3,
Giuseppe Graldi
3 and
Angelina Passaro
1,4,*
1
Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy
2
Department of General Surgery, Ospedale del Delta, 44023 Lagosanto, Italy
3
Blood Transfusion Service, University Hospital of Ferrara Arcispedale Sant’Anna, Cona, 44124 Ferrara, Italy
4
Medical Department, Unit of Internal Medicine, University Hospital of Ferrara Arcispedale Sant’Anna, Cona, 44124 Ferrara, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2021, 13(3), 9177; https://doi.org/10.4081/hr.2021.9177
Submission received: 12 April 2021 / Revised: 14 May 2021 / Accepted: 25 May 2021 / Published: 6 September 2021

Abstract

The current literature still gives a little information about the relationships between the ABO blood group system and the immune response to the virus or the different disease outcomes. Hypothesizing the presence of a predisposition by some blood groups to COVID-19, we searched for differences between patients towards the different outcomes of disease.We enrolled 330 inpatients with a diagnosis of COVID-19, determining both their ABO blood group system and Rh factor, collecting demographic, clinical and laboratory data. We searched for relationships with COVID-19 outcomes within an observation period of 180 days (Intensification of Care-IoC, Inhospital death, 180-days mortality). The most frequent ABO blood group was A (45.8%); a minor part was represented by group O (38.8%), B (11.5%), AB (3.9%). As for the Rh factor, 86.7% of patients were Rh-positive. There were no significant differences between blood groups and Rh factors as for age, length of hospital stays (LoS), or Charlson Comorbidity Index (CCI), nor we found significant relationships between the ABO groups and COVID-19 outcomes. A significant relation was found between AB group and IoC (p = 0.03) while as for the Rh factor, the patients with Rh factor positive died with less frequency during the stay (p = 0.03). Cox regression analyses showed substantial differences in the survival functions concerning the Rh factors. The Rh factor seems to be involved in the 180-day prognosis. The survival functions of patients with Rh factor positive show, in fact, significantly better curves when compared to those with Rh factor negative.
Keywords: coronavirus; COVID-19; Rh factor; blood groups coronavirus; COVID-19; Rh factor; blood groups

Share and Cite

MDPI and ACS Style

Greco, S.; Fabbri, N.; Bella, A.; Bonsi, B.; Violi, A.; Fortunato, V.; Govoni, M.; Graldi, G.; Passaro, A. COVID-19 and Blood Groups: A Six-Months Observational Study in Ferrara, Italy. Hematol. Rep. 2021, 13, 9177. https://doi.org/10.4081/hr.2021.9177

AMA Style

Greco S, Fabbri N, Bella A, Bonsi B, Violi A, Fortunato V, Govoni M, Graldi G, Passaro A. COVID-19 and Blood Groups: A Six-Months Observational Study in Ferrara, Italy. Hematology Reports. 2021; 13(3):9177. https://doi.org/10.4081/hr.2021.9177

Chicago/Turabian Style

Greco, Salvatore, Nicolò Fabbri, Alessandro Bella, Beatrice Bonsi, Alessandra Violi, Valeria Fortunato, Maurizio Govoni, Giuseppe Graldi, and Angelina Passaro. 2021. "COVID-19 and Blood Groups: A Six-Months Observational Study in Ferrara, Italy" Hematology Reports 13, no. 3: 9177. https://doi.org/10.4081/hr.2021.9177

APA Style

Greco, S., Fabbri, N., Bella, A., Bonsi, B., Violi, A., Fortunato, V., Govoni, M., Graldi, G., & Passaro, A. (2021). COVID-19 and Blood Groups: A Six-Months Observational Study in Ferrara, Italy. Hematology Reports, 13(3), 9177. https://doi.org/10.4081/hr.2021.9177

Article Metrics

Back to TopTop