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Hematology Reports
  • Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
  • Case Report
  • Open Access

12 March 2021

Hemorrhagic Cystitis: A Successful Outcome for a Challenging Complication in Stem Cell Transplant

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1
Department of Hematology and Hemotherapy, Avenida Cesareo Alierta Number 10—Right Staircase—5th Floor—Door Centro, 50009 Zaragoza, Spain
2
Department of Anatomical Pathology, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain
*
Author to whom correspondence should be addressed.

Abstract

Hemorrhagic cystitis (HC) secondary to BK polyomavirus (BKPyV) is a frequent complication related to allogenic stem cell transplantation. With an important morbidity and mortality, this disease doesn’t have a stablished standard treatment or prophylaxis strategies. At this moment, the supportive therapies approved to treat included hyperhydration, forced diuresis and transfusion support. Cidofovir is a nucleotide analog of deoxycytidine monophosphate against DNA viruses and it has been described for the treatment of BKPyV-HC, but at this moment, is not a front-line therapy. We report a successful case after the use of Cidofovir without Probenecid. No adverse effect was developed under the treatment, and after 4 weeks of treatment, the patient achieved an excellent response.

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