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Pediatric Reports
Volume 8
Issue 3
10.4081/pr.2016.6615
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Case Report

Mild Encephalopathy with Reversible Lesions in the Splenium of Corpus Callosum and Bilateral Cerebral Deep white Matter in Identical twins

by
Junko Tahara
1,
Jun Shinozuka
1,
Hitoshi Awaguni
1,
Shin-ichiro Tanaka
1,
Shigeru Makino
1,
Rikken Maruyama
1 and
Shinsaku Imashuku
2,*
1
Division of Pediatrics
2
Division of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji, Kyoto, Japan
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2016, 8(3), 6615; https://doi.org/10.4081/pr.2016.6615
Submission received: 21 May 2016 / Revised: 3 August 2016 / Accepted: 3 August 2016 / Published: 19 September 2016

Abstract

Identical twin brothers developed mild encephalopathy at the age of 7.0 and 9.7 years (Patient 1) and 10.7 years (Patient 2). Patient 1 had influenza A at the time of his second episode, but triggering agents were not evident at the first episode. The triggering agents in Patient 2 were unclear. The neurological features of both patients included transient facial numbness, left arm paresis, dysarthria, and gait disturbance. Diffusion-weighted images from magnetic resonance imaging showed high signal levels at the splenium of corpus callosum and in the bilateral cerebral deep white matter. These results are characteristic of mild encephalitis/encephalopathy with a reversible isolated splenium of corpus callosum lesion. All three episodes were treated with a methylprednisolone pulse. Acyclovir was also administered to Patient 2 and to Patient 1 during his first episode. Patient 1 received an anti-influenza agent and intravenous immunoglobulin during his second episode. Both patients recovered completely without sequelae. Genetic factors, which may predispose identical twins to develop encephalopathy, are discussed.
Keywords: Encephalopathy; Splenial lesion; Corpus callosum; Identical twins Encephalopathy; Splenial lesion; Corpus callosum; Identical twins

Share and Cite

MDPI and ACS Style

Tahara, J.; Shinozuka, J.; Awaguni, H.; Tanaka, S.-i.; Makino, S.; Maruyama, R.; Imashuku, S. Mild Encephalopathy with Reversible Lesions in the Splenium of Corpus Callosum and Bilateral Cerebral Deep white Matter in Identical twins. Pediatr. Rep. 2016, 8, 6615. https://doi.org/10.4081/pr.2016.6615

AMA Style

Tahara J, Shinozuka J, Awaguni H, Tanaka S-i, Makino S, Maruyama R, Imashuku S. Mild Encephalopathy with Reversible Lesions in the Splenium of Corpus Callosum and Bilateral Cerebral Deep white Matter in Identical twins. Pediatric Reports. 2016; 8(3):6615. https://doi.org/10.4081/pr.2016.6615

Chicago/Turabian Style

Tahara, Junko, Jun Shinozuka, Hitoshi Awaguni, Shin-ichiro Tanaka, Shigeru Makino, Rikken Maruyama, and Shinsaku Imashuku. 2016. "Mild Encephalopathy with Reversible Lesions in the Splenium of Corpus Callosum and Bilateral Cerebral Deep white Matter in Identical twins" Pediatric Reports 8, no. 3: 6615. https://doi.org/10.4081/pr.2016.6615

APA Style

Tahara, J., Shinozuka, J., Awaguni, H., Tanaka, S. -i., Makino, S., Maruyama, R., & Imashuku, S. (2016). Mild Encephalopathy with Reversible Lesions in the Splenium of Corpus Callosum and Bilateral Cerebral Deep white Matter in Identical twins. Pediatric Reports, 8(3), 6615. https://doi.org/10.4081/pr.2016.6615

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