Pathobiology of ALK-Negative Anaplastic Large Cell Lymphoma

Stefano A. Pileri; Claudio Agostinelli; Francesco Bacci; Elena Sabattini; Carlo Sagramoso; Brunangelo Falini; Pier Paolo Piccaluga

doi:10.4081/pr.2011.s2.e5

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Article

17 June 2011

Pathobiology of ALK-Negative Anaplastic Large Cell Lymphoma

and

Hematopathology Section, Departmentof Hematology and Oncological Sciences“L. and A. Seràgnoli”, S. Orsola-MalpighiHospital, University of Bologna, Bologna,Italy

Institute of Haematology, SilvestriniHospital, University of Perugia, Perugia,Italy

Author to whom correspondence should be addressed.

Pediatr. Rep.2011, 3(s2), e5;https://doi.org/10.4081/pr.2011.s2.e5

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Abstract

The authors revise the concept of ALK-negative anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated as well as the phenotypic, molecular and clinical characteristics. Finally, the biological rationale for possible innovative targeted therapies is presented.

Keywords:

ALK-negative anaplastic large cell lymphoma

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