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Pediatric Reports
Volume 3
Issue s2
10.4081/pr.2011.s2.e5
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Article

Pathobiology of ALK-Negative Anaplastic Large Cell Lymphoma

by
Stefano A. Pileri
1,*,
Claudio Agostinelli
,
Francesco Bacci
,
Elena Sabattini
,
Carlo Sagramoso
,
Brunangelo Falini
and
Pier Paolo Piccaluga
1
Hematopathology Section, Departmentof Hematology and Oncological Sciences“L. and A. Seràgnoli”, S. Orsola-MalpighiHospital, University of Bologna, Bologna,Italy
2
Institute of Haematology, SilvestriniHospital, University of Perugia, Perugia,Italy
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2011, 3(s2), e5; https://doi.org/10.4081/pr.2011.s2.e5
Submission received: 4 May 2011 / Accepted: 4 June 2011 / Published: 17 June 2011

Abstract

The authors revise the concept of ALK-negative anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated as well as the phenotypic, molecular and clinical characteristics. Finally, the biological rationale for possible innovative targeted therapies is presented.
Keywords: ALK-negative anaplastic large cell lymphoma ALK-negative anaplastic large cell lymphoma

Share and Cite

MDPI and ACS Style

Pileri, S.A.; Agostinelli, C.; Bacci, F.; Sabattini, E.; Sagramoso, C.; Falini, B.; Piccaluga, P.P. Pathobiology of ALK-Negative Anaplastic Large Cell Lymphoma. Pediatr. Rep. 2011, 3, e5. https://doi.org/10.4081/pr.2011.s2.e5

AMA Style

Pileri SA, Agostinelli C, Bacci F, Sabattini E, Sagramoso C, Falini B, Piccaluga PP. Pathobiology of ALK-Negative Anaplastic Large Cell Lymphoma. Pediatric Reports. 2011; 3(s2):e5. https://doi.org/10.4081/pr.2011.s2.e5

Chicago/Turabian Style

Pileri, Stefano A., Claudio Agostinelli, Francesco Bacci, Elena Sabattini, Carlo Sagramoso, Brunangelo Falini, and Pier Paolo Piccaluga. 2011. "Pathobiology of ALK-Negative Anaplastic Large Cell Lymphoma" Pediatric Reports 3, no. s2: e5. https://doi.org/10.4081/pr.2011.s2.e5

APA Style

Pileri, S. A., Agostinelli, C., Bacci, F., Sabattini, E., Sagramoso, C., Falini, B., & Piccaluga, P. P. (2011). Pathobiology of ALK-Negative Anaplastic Large Cell Lymphoma. Pediatric Reports, 3(s2), e5. https://doi.org/10.4081/pr.2011.s2.e5

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