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Article

Aplastic Anemia: Immunosuppressive Therapy in 2010

Department of Biochemistry and MedicalBiotechnologies, Federico II University of Naples, Naples, Italy
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2011, 3(s2), e7; https://doi.org/10.4081/pr.2011.s2.e7
Submission received: 4 May 2011 / Accepted: 4 June 2011 / Published: 17 June 2011

Abstract

Acquired aplastic anemia (AA) is the typical bone marrow failure syndrome characterized by an empty bone marrow; an immune-mediated pathophysiology has been demonstrated by experimental works as well as by clinical observations. Immunusuppressive therapy (IST) is a key treatment strategy for aplastic anemia; since 20 years the standard IST for AA patients has been anti-thymocyte globuline (ATG) plus cyclosporine A (CyA), which results in response rates ranging between 50% and 70%, and even higher overall survival. However, primary and secondary failures after IST remain frequent, and to date all attempts aiming to overcome this problem have been unfruitful. Here we review the state of the art of IST for AA in 2010, focusing on possible strategies to improve current treatments. We also discuss very recent data which question the equality of different ATG preparations, leading to a possible reconsideration of the current standards of care for AA patients.
Keywords: aplastic anemia; immunosuppressive therapy aplastic anemia; immunosuppressive therapy

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MDPI and ACS Style

Risitano, A.M.; Perna, F. Aplastic Anemia: Immunosuppressive Therapy in 2010. Pediatr. Rep. 2011, 3, e7. https://doi.org/10.4081/pr.2011.s2.e7

AMA Style

Risitano AM, Perna F. Aplastic Anemia: Immunosuppressive Therapy in 2010. Pediatric Reports. 2011; 3(s2):e7. https://doi.org/10.4081/pr.2011.s2.e7

Chicago/Turabian Style

Risitano, Antonio M., and Fabiana Perna. 2011. "Aplastic Anemia: Immunosuppressive Therapy in 2010" Pediatric Reports 3, no. s2: e7. https://doi.org/10.4081/pr.2011.s2.e7

APA Style

Risitano, A. M., & Perna, F. (2011). Aplastic Anemia: Immunosuppressive Therapy in 2010. Pediatric Reports, 3(s2), e7. https://doi.org/10.4081/pr.2011.s2.e7

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