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Microbiology Research, Volume 16, Issue 2

2025 February - 24 articles

Cover Story: The wound microbiome refers to the specific community of microbes, including bacteria, fungi, and other microorganisms, that are present in and around a wound. This microbiome plays a crucial role in wound healing, as it includes both healing-promoting and pathogenic microbes. A balanced microbial colonization can support wound healing and prevent infections, while an overgrowth of pathogenic microbes can lead to delayed healing processes and complications. This review highlighted the complex interactions in the wound microbiome and discussed the importance of non-pathogenic microbes for wound healing. In addition, possible therapeutic approaches to restoring a healthy microbiome and preventing infections will be addressed. A deeper understanding of these dynamics could open up new perspectives for the treatment of wounds and the development of strategies to combat wound infections. View this paper
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Articles (24)

  • Article
  • Open Access
1,133 Views
13 Pages

To study the relationship between the microbial community structure and the quality of alfalfa silage by adding alfalfa-fermented green juice (aFGJ), the Box–Behnken design was used to optimize the process of preparing aFGJ. High-throughput seq...

  • Article
  • Open Access
3 Citations
9,148 Views
13 Pages

Diode Laser and Red-Laser Photodynamic Therapy with Toluidine Blue Gel for the Treatment of Onychomycosis: A Case Series

  • Sara García-Oreja,
  • Francisco Javier Álvaro-Afonso,
  • Aroa Tardáguila-García,
  • David Navarro-Pérez,
  • Esther Alicia García-Morales and
  • José Luis Lázaro-Martínez

Background: Onychomycosis is the most prevalent nail disease, posing a challenge for health professionals in terms of treatment. Conventional topical antifungal treatments can often prove insufficient, and the use of oral antifungal drugs carries a h...

  • Article
  • Open Access
3 Citations
3,322 Views
14 Pages

Iron uptake plays an important role in the persistence of Escherichia coli in the host and for its survival in the environment, and it is known that E. coli has a variety of siderophore systems for iron uptake. We investigated the ability to produce...

  • Article
  • Open Access
935 Views
9 Pages

Hydroethanolic Extract of Punica granatum Inhibits Cryptococcus by Depolarising Mitochondrial Membranes

  • Julliana Ribeiro Alves Santos,
  • Brenda Letícia Araujo Motta,
  • Haryne Lizandrey Azevedo Furtado,
  • Alessandra Teixeira de Macedo,
  • Alexsander Rodrigues Carvalho Junior,
  • Lídio Gonçalves Lima Neto,
  • Aruanã Joaquim Matheus Costa Rodrigues Pinheiro,
  • Cibelle Raphaela da Silva Cavalcante Moreira,
  • Luís Cláudio Nascimento da Silva and
  • Rodrigo Assuncao Holanda

Cryptococcal infections are distributed worldwide and mainly caused by Cryptococcus neoformans and Cryptococcus gattii. The reduced number of antifungals and increasing number of cases of resistance require the search for new therapeutic options, suc...

  • Article
  • Open Access
7 Citations
2,197 Views
15 Pages

Objectives: Bacterial infections, mainly due to rising antimicrobial resistance (AMR), are an immense global health threat, complicating treatment, prolonging illness, and increasing mortality. The WHO lists AMR as one of the major threats to human h...

  • Article
  • Open Access
3 Citations
1,788 Views
21 Pages

Soil is the most dynamic matrix in the environment and where biogeochemical cycles take place through the activities of microorganisms such as bacteria. A 16S rRNA sequence analysis of seven different soil samples from different geographical location...

  • Review
  • Open Access
12 Citations
9,936 Views
38 Pages

The existence of biofilms as heterogeneous structures, comprising bacterial cells embedded in a self-synthesized polymeric matrix and adhered to biotic and abiotic surfaces, exhibiting high antibiotic tolerance, is a fact that, in recent years, has e...

  • Article
  • Open Access
2 Citations
3,078 Views
17 Pages

Burden of Multidrug-Resistant Organisms in Oman: A Six-Year Single-Study Calling for Urgent Actions

  • Mohammed Abdullah Al Shuhoumi,
  • Suleiman Al Ghafri,
  • Fareed J. Hameed,
  • Asma Al Hinai,
  • Abir Al Ghafri,
  • Sathiya R. Mony,
  • Bader Al Sawafi,
  • Gopinath Govindaraj,
  • Asma Al Yaqoobi and
  • Abdulrahman Al Mhrooqi
  • + 3 authors

Background: Healthcare facilities worldwide are struggling to combat the increasing prevalence of multidrug-resistant organisms (MDROs). MDROs pose a serious threat to patient safety, resulting in longer hospital stays, higher healthcare expenses, an...

  • Communication
  • Open Access
1,364 Views
10 Pages

In Vitro Preliminary Evaluation of a New Rifamycin In Situ Gelling Formulation for Pouchitis Treatment

  • Caterina Aiello,
  • Cinzia Quattrocchi,
  • Rosario Musumeci,
  • Daria Nicolosi,
  • Giulio Petronio Petronio and
  • Roberto Di Marco

Pouchitis is one of the most common long-term complications after ileal pouch–anal anastomosis (IPAA) surgery, with a reported incidence rate of up to 50%. Identifying specific bacteria involved in the pathogenesis has important implications fo...

  • Article
  • Open Access
4 Citations
2,250 Views
10 Pages

Leptospira interrogans Associated with the Common Vampire Bat (Desmodus rotundus) from the Neotropical Region of Mexico

  • Laura A. Chong-Guzmán,
  • Nidia Aréchiga-Ceballos,
  • Gerardo G. Ballados-Gonzáles,
  • Carlos I. Miranda-Caballero,
  • Estefanía Grostieta,
  • Mariel Aguilar-Domínguez,
  • Dora Romero-Salas,
  • Rosa I. Hernández-Herrera,
  • Pablo San Martín-del Ángel and
  • Sokani Sanchez-Montes
  • + 4 authors

The genus Leptospira includes at least 69 Gram-negative, aerobic spirochetes, of which 25 are pathogenic and associated with a diverse range of mammals, including members of the order Chiroptera. On the American continent, there are six confirmed Lep...

  • Brief Report
  • Open Access
2 Citations
3,507 Views
7 Pages

Hyperinfection by Strongyloides stercoralis: Series of Cases in a Regional Hospital in Southern Spain

  • Ana Lucas-Dato,
  • María Dolores Hernández-Rabadán,
  • Pedro Luis Boils Arroyo and
  • Jara Llenas-García

Background: Strongyloidiasis is a neglected tropical disease caused by the nematode Strongyloides stercoralis. In immunosuppressed patients, it may progress to hyperinfection syndrome (HIS) and disseminated strongyloidiasis (DS), both of which are as...

  • Article
  • Open Access
2 Citations
1,807 Views
12 Pages

The Effect of an Early-Life Lactiplantibacillus plantarum LPJZ-658 Intervention on Performance and Gut Microbiota in Suckling Piglets

  • Zuopeng Chen,
  • Ziqi Liu,
  • Chen Chen,
  • Yanjun Fu,
  • Haiyang Wang,
  • Cuiqing Zhao,
  • Jiali Zhang and
  • Liming Liu

This study aimed to investigate the effects of early-life supplementation with Lactiplantibacillus plantarum LPJZ-658 on the growth performance and gut microbiota of newborn piglets. Twelve one-day-old suckling piglets were randomly divided into two...

  • Article
  • Open Access
1,577 Views
17 Pages

Transcriptomic Response of Balamuthia mandrillaris to Lippia graveolens Extract Fractions

  • Leobardo Daniel Gonzalez-Zuñiga,
  • Jose Reyes Gonzalez-Galaviz,
  • Abraham Cruz-Mendívil,
  • Fernando Lares Villa,
  • Erick Paul Gutiérrez-Grijalva,
  • Jaime López-Cervantes,
  • Dalia I. Sánchez-Machado,
  • Luis Fernando Lares-Jiménez and
  • Libia Zulema Rodriguez-Anaya

Balamuthia mandrillaris is a free-living amoeba pathogenic to humans, causing amoebic granulomatous encephalitis (GAE). Due to the associated mortality rates of <95%, the absence of treatments, and a clear understanding of the pathogenesis of this...

  • Review
  • Open Access
6 Citations
4,351 Views
13 Pages

Pathogenic and Non-Pathogenic Microbes in the Wound Microbiome—How to Flip the Switch

  • Sophie Charlotte Liegenfeld,
  • Svenja Stenzel,
  • Julian-Dario Rembe,
  • Mandy Dittmer,
  • Paulo Ramos and
  • Ewa Klara Stuermer

The wound microbiome refers to the specific community of microbes, including bacteria, fungi, and other microorganisms, that are present in and around a wound. This microbiome plays a crucial role in wound healing, as it includes both healing-promoti...

  • Communication
  • Open Access
1,255 Views
10 Pages

Research on microbiota has underscored the crucial influence of microbial communities on numerous biological functions that yield positive outcomes for the host, such as digestion, nutrient metabolism, resistance against pathogen invasion, and growth...

  • Review
  • Open Access
1 Citations
3,234 Views
24 Pages

Influenza A virus (IAV) is a widespread human respiratory pathogen that contributes significantly to morbidity and mortality worldwide. The adsorption of the virus into the cell surface is the earliest stage of its replication cycle. The key role of...

  • Article
  • Open Access
1,435 Views
17 Pages

Effect of Carotenoid Composition on Stability and Light-Induced Oxidative Damage of the LH2 Complexes Isolated from Ectothiorhodospira haloalkaliphila

  • Denis V. Yanykin,
  • Mark O. Paskhin,
  • Sergey A. Shumeyko,
  • Aleksandr A. Ashikhmin and
  • Maxim A. Bolshakov

Earlier, it has been shown that carotenoid-dependent singlet oxygen photogeneration in LH2 of Ectothiorhodospira haloalkaliphila leads to damage to pigments and protein. Present work continues this investigation using LH2 complexes with altered carot...

  • Article
  • Open Access
2 Citations
3,054 Views
15 Pages

Biological Control of Sclerotinia sclerotiorum on Greenhouse Lettuce Using Trichoderma koningiopsis Agg

  • Snježana Topolovec-Pintarić,
  • Ana Maria Kovaček,
  • Olga Malev,
  • Ivana Kušan,
  • Neven Matočec,
  • Ana Pošta,
  • Lucia Pole and
  • Armin Mešić

The lettuce drop or white mold is an economically important disease as the causal fungus Sclerotinia sclerotiorum can infect the lettuce at any stage of plant development. Polyphagous nature of S. sclerotiorum, the longevity of soil-borne sclerotia a...

  • Article
  • Open Access
2 Citations
2,100 Views
27 Pages

Enterobacter soli Strain AF-22b-4245: Study of the Genome and the Effect on Wheat Growth

  • Ekaterina Alexeevna Sokolova,
  • Olga Viktorovna Mishukova,
  • Inna Viktorovna Khlistun,
  • Irina Nikolaevna Tromenschleger,
  • Evgeniya Vladimirovna Chumanova and
  • Elena Nikolaevna Voronina

Background: In this work the plant growth-promoting (PGP) qualities of the Enterobacter soli strain AF-22b-4245 were studied, including screening tests for PGP, whole genome sequencing (WGS) and genome annotation, and greenhouse experiments on wheat....

  • Article
  • Open Access
1 Citations
1,340 Views
13 Pages

Sex Differences and Pathogen Patterns in Surgically Treated Aortic Valve Endocarditis over 15 Years

  • Elisa Mikus,
  • Mariafrancesca Fiorentino,
  • Diego Sangiorgi,
  • Antonino Costantino,
  • Simone Calvi,
  • Elena Tenti,
  • Elena Tremoli,
  • Alberto Tripodi and
  • Carlo Savini

Background: Infective endocarditis (IE) is a serious public health concern due to its high morbidity and lethality. This study investigates epidemiological trends in aortic valve endocarditis, focusing on sex-related differences in microbial etiology...

  • Article
  • Open Access
1 Citations
2,056 Views
12 Pages

In Vitro Evaluation of the Antiviral Properties of Exogenous mRNA Encoding the Human MxA Protein

  • Marina A. Plotnikova,
  • Ekaterina A. Romanovskaya-Romanko,
  • Anastasia A. Pulkina,
  • Marina A. Shuklina,
  • Anna-Polina S. Shurygina and
  • Sergey A. Klotchenko

MxA is a cytoplasmic protein induced in human cells exposed to type I and III interferons. It can inhibit various viruses, including influenza A, by blocking the early steps of the viral replication cycle. The rapid advancement of mRNA-based technolo...

  • Case Report
  • Open Access
2,350 Views
15 Pages

First Isolation, Molecular Identification, and Phylogenetic Characterization of A3B5 Very Virulent Infectious Bursal Disease Virus in Pullets in Chile

  • Leandro Cádiz,
  • Miguel Guzmán,
  • Paola Rivera,
  • Fernando Navarrete,
  • Paulina Torres and
  • Héctor Hidalgo

Infectious bursal disease virus (IBDV) is an important pathogen affecting the poultry industry worldwide. IBDV serotype 1, including classical virulent strains (cvIBDV), variant strains (varIBDV), and very virulent strains (vvIBDV), is pathogenic for...

  • Article
  • Open Access
1 Citations
3,244 Views
15 Pages

Trends and Patterns of Antimicrobial Resistance in a Tertiary Care Hospital in Bangladesh

  • Sangjukta Roy,
  • Hridika Talukder Barua,
  • Mohammad Julhas Sujan,
  • Akram Hossain,
  • Shyamal Kumar Paul,
  • Syeda Anjuman Nasreen,
  • Salma Ahmed,
  • Nazia Haque,
  • Zakir Hossain Habib and
  • Nimesh Poudyal
  • + 8 authors

Introduction: Antimicrobial resistance (AMR) is a global public health issue, particularly in resource-limited, low- to middle-income countries like Bangladesh. In this study, we analyze and present four years of data on AMR from a tertiary care hosp...

  • Article
  • Open Access
1 Citations
1,563 Views
17 Pages

Zoonotic Foodborne Infections in a Tertiary Healthcare Setting: Clinical and Epidemiological Aspects of Campylobacter and Salmonella Infection in Northern Portugal in 2010–2020

  • Maria Inês Matos,
  • Rafael Rocha,
  • João Pinto,
  • André Guimarães,
  • Rita Lino,
  • Maria Helena Rocha,
  • Marta Patacho,
  • Raquel Duro,
  • Lurdes Santos and
  • Jorge Almeida

This study aimed to describe the epidemiology, clinical presentation, and management of Campylobacter sp. and Salmonella sp. infections in a tertiary hospital in Northern Portugal (2010–2020) and identify factors associated with reporting, inva...

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Microbiol. Res. - ISSN 2036-7481