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Article

Renal Artery Catheterization for Microcapsules’ Targeted Delivery to the Mouse Kidney

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Science Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia
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Center for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobel Str., 143005 Moscow, Russia
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Institute of Medicine, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, Russia
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Department of Medical Nanobiotecnology, Pirogov Russian National Research Medical University, 1 Ostrovityanova Str., 117997 Moscow, Russia
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Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 3 Nobel Str., 143005 Moscow, Russia
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School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK
*
Authors to whom correspondence should be addressed.
Academic Editor: Piroska Szabó-Révész
Pharmaceutics 2022, 14(5), 1056; https://doi.org/10.3390/pharmaceutics14051056
Received: 17 April 2022 / Revised: 7 May 2022 / Accepted: 12 May 2022 / Published: 14 May 2022
The problem of reducing the side effects associated with drug distribution throughout the body in the treatment of various kidney diseases can be solved by effective targeted drug delivery. The method described herein involves injection of a drug encapsulated in polyelectrolyte capsules to achieve prolonged local release and long-term capillary retention of several hours while these capsules are administered via the renal artery. The proposed method does not imply disruption (puncture) of the renal artery or aorta and is suitable for long-term chronic experiments on mice. In this study, we compared how capsule size and dosage affect the target kidney blood flow. It has been established that an increase in the diameter of microcapsules by 29% (from 3.1 to 4.0 μm) requires a decrease in their concentration by at least 50% with the same suspension volume. The photoacoustic method, along with laser speckle contrast imaging, was shown to be useful for monitoring blood flow and selecting a safe dose. Capsules contribute to a longer retention of a macromolecular substance in the target kidney compared to its free form due to mechanical retention in capillaries and slow impregnation into surrounding tissues during the first 1–3 h, which was shown by fluorescence tomography and microscopy. At the same time, the ability of capillaries to perform almost complete “self-cleaning” from capsular shells during the first 12 h leads to the preservation of organ tissues in a normal state. The proposed strategy, which combines endovascular surgery and the injection of polymer microcapsules containing the active substance, can be successfully used to treat a wide range of nephropathies. View Full-Text
Keywords: renal artery catheterization; polyelectrolyte microcapsules; targeted delivery; mouse kidney; biodistribution; migration; blood flow; optoacoustic mesoscopy; laser speckle contrast imaging renal artery catheterization; polyelectrolyte microcapsules; targeted delivery; mouse kidney; biodistribution; migration; blood flow; optoacoustic mesoscopy; laser speckle contrast imaging
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MDPI and ACS Style

Gusliakova, O.I.; Prikhozhdenko, E.S.; Plastun, V.O.; Mayorova, O.A.; Shushunova, N.A.; Abdurashitov, A.S.; Kulikov, O.A.; Abakumov, M.A.; Gorin, D.A.; Sukhorukov, G.B.; Sindeeva, O.A. Renal Artery Catheterization for Microcapsules’ Targeted Delivery to the Mouse Kidney. Pharmaceutics 2022, 14, 1056. https://doi.org/10.3390/pharmaceutics14051056

AMA Style

Gusliakova OI, Prikhozhdenko ES, Plastun VO, Mayorova OA, Shushunova NA, Abdurashitov AS, Kulikov OA, Abakumov MA, Gorin DA, Sukhorukov GB, Sindeeva OA. Renal Artery Catheterization for Microcapsules’ Targeted Delivery to the Mouse Kidney. Pharmaceutics. 2022; 14(5):1056. https://doi.org/10.3390/pharmaceutics14051056

Chicago/Turabian Style

Gusliakova, Olga I., Ekaterina S. Prikhozhdenko, Valentina O. Plastun, Oksana A. Mayorova, Natalia A. Shushunova, Arkady S. Abdurashitov, Oleg A. Kulikov, Maxim A. Abakumov, Dmitry A. Gorin, Gleb B. Sukhorukov, and Olga A. Sindeeva. 2022. "Renal Artery Catheterization for Microcapsules’ Targeted Delivery to the Mouse Kidney" Pharmaceutics 14, no. 5: 1056. https://doi.org/10.3390/pharmaceutics14051056

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