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Article

Well-Defined Polyethylene Glycol Microscale Hydrogel Blocks Containing Gold Nanorods for Dual Photothermal and Chemotherapeutic Therapy

1
Leibniz-Institut für Polymerforschung Dresden e.V., Max Bergmann Center of Biomaterials Dresden, Hohe Str. 6, 01069 Dresden, Germany
2
School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK
3
Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, 13344 Marseille, France
4
Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44242, USA
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Charles Institute of Dermatology, School of Medicine, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland
6
Center for Regenerative Therapies Dresden and Cluster of Excellence Physics of Life, Technische Universität Dresden, 01062 Dresden, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Jun Dai
Pharmaceutics 2022, 14(3), 551; https://doi.org/10.3390/pharmaceutics14030551
Received: 17 January 2022 / Revised: 11 February 2022 / Accepted: 14 February 2022 / Published: 28 February 2022
Local drug delivery offers a means of achieving a high concentration of therapeutic agents directly at the tumor site, whilst minimizing systemic toxicity. For heterogenous cancers such as glioblastoma, multimodal therapeutic approaches hold promise for better efficacy. Herein, we aimed to create a well-defined and reproducible drug delivery system that also incorporates gold nanorods for photothermal therapy. Solvent-assisted micromolding was used to create uniform sacrificial templates in which microscale hydrogels were formed with and without gold nanorods throughout their structure. The microscale hydrogels could be loaded with doxorubicin, releasing it over a period of one week, causing toxicity to glioma cells. Since these microscale hydrogels were designed for direct intratumoral injection, therefore bypassing the blood–brain barrier, the highly potent breast cancer therapeutic doxorubicin was repurposed for use in this study. By contrast, the unloaded hydrogels were well tolerated, without decreasing cell viability. Irradiation with near-infrared light caused heating of the hydrogels, showing that if concentrated at an injection site, these hydrogels maybe able to cause anticancer activity through two separate mechanisms. View Full-Text
Keywords: glioblastoma; photodynamic therapy; microscale hydrogels; polyethylene glycol; gold nanorods glioblastoma; photodynamic therapy; microscale hydrogels; polyethylene glycol; gold nanorods
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MDPI and ACS Style

Newland, B.; Starke, J.; Bastiancich, C.; Gonçalves, D.P.N.; Bray, L.J.; Wang, W.; Werner, C. Well-Defined Polyethylene Glycol Microscale Hydrogel Blocks Containing Gold Nanorods for Dual Photothermal and Chemotherapeutic Therapy. Pharmaceutics 2022, 14, 551. https://doi.org/10.3390/pharmaceutics14030551

AMA Style

Newland B, Starke J, Bastiancich C, Gonçalves DPN, Bray LJ, Wang W, Werner C. Well-Defined Polyethylene Glycol Microscale Hydrogel Blocks Containing Gold Nanorods for Dual Photothermal and Chemotherapeutic Therapy. Pharmaceutics. 2022; 14(3):551. https://doi.org/10.3390/pharmaceutics14030551

Chicago/Turabian Style

Newland, Ben, Johannes Starke, Chiara Bastiancich, Diana P. N. Gonçalves, Laura J. Bray, Wenxin Wang, and Carsten Werner. 2022. "Well-Defined Polyethylene Glycol Microscale Hydrogel Blocks Containing Gold Nanorods for Dual Photothermal and Chemotherapeutic Therapy" Pharmaceutics 14, no. 3: 551. https://doi.org/10.3390/pharmaceutics14030551

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