Pharmaceutics, Volume 14, Issue 3
2022 March - 216 articles
Cover Story: The self-defense mechanism of cancer cells, known as autophagy, and un-sustained ROS generation often restricts efficiency, lowering the immune attack, especially in invading metastatic clusters. Fenton-like reactions in cancer cells cause intratumoral generation of ROS, allowing the potential for immune therapy of tumor metastasis via the recognition of tumor-associated antigens. In this paper, a functional core–shell metal–organic framework nano-cube (dual MOF) as a programmed peroxide mimic in the cancer cells, doubling as a catalytic agent and T cell infiltration inducer that programs ROS and inhibits autophagy, is reported. Such synergy of T cell recruitment and ROS generation transported by dual MOF during metastases successfully suppresses more than 90% of tumor foci in the lung. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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