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Article

Impact of Powder Properties on the Rheological Behavior of Excipients

1
DFE Pharma, Klever Str. 187, 47574 Goch, Germany
2
Granutools, Rue Jean-Lambert Defrêne, 107, 4340 Awans, Belgium
*
Author to whom correspondence should be addressed.
Academic Editor: Colin Hare
Pharmaceutics 2021, 13(8), 1198; https://doi.org/10.3390/pharmaceutics13081198
Received: 30 June 2021 / Revised: 30 July 2021 / Accepted: 2 August 2021 / Published: 4 August 2021
(This article belongs to the Special Issue Recent Advances in Secondary Processing of Pharmaceutical Powders)
With the emergence of quality by design in the pharmaceutical industry, it becomes imperative to gain a deeper mechanistic understanding of factors impacting the flow of a formulation into tableting dies. Many flow characterization techniques are present, but so far only a few have shown to mimic the die filling process successfully. One of the challenges in mimicking the die filling process is the impact of rheological powder behavior as a result of differences in flow field in the feeding frame. In the current study, the rheological behavior was investigated for a wide range of excipients with a wide range of material properties. A new parameter for rheological behavior was introduced, which is a measure for the change in dynamic cohesive index upon changes in flow field. Particle size distribution was identified as a main contributing factor to the rheological behavior of powders. The presence of fines between larger particles turned out to reduce the rheological index, which the authors explain by improved particle separation at more dynamic flow fields. This study also revealed that obtained insights on rheological behavior can be used to optimize agitator settings in a tableting machine. View Full-Text
Keywords: powder flow; die filling; powder rheology; dynamic cohesive index; excipients; tableting; continuous manufacturing; quality by design powder flow; die filling; powder rheology; dynamic cohesive index; excipients; tableting; continuous manufacturing; quality by design
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MDPI and ACS Style

Janssen, P.H.M.; Depaifve, S.; Neveu, A.; Francqui, F.; Dickhoff, B.H.J. Impact of Powder Properties on the Rheological Behavior of Excipients. Pharmaceutics 2021, 13, 1198. https://doi.org/10.3390/pharmaceutics13081198

AMA Style

Janssen PHM, Depaifve S, Neveu A, Francqui F, Dickhoff BHJ. Impact of Powder Properties on the Rheological Behavior of Excipients. Pharmaceutics. 2021; 13(8):1198. https://doi.org/10.3390/pharmaceutics13081198

Chicago/Turabian Style

Janssen, Pauline H.M., Sébastien Depaifve, Aurélien Neveu, Filip Francqui, and Bastiaan H.J. Dickhoff. 2021. "Impact of Powder Properties on the Rheological Behavior of Excipients" Pharmaceutics 13, no. 8: 1198. https://doi.org/10.3390/pharmaceutics13081198

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