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Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

1
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
2
Department of Medicine and Surgery, University of Salerno, 84082 Baronissi, Italy
3
PhD Program in Drug Discovery and Development, Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Maria Nowakowska
Pharmaceutics 2021, 13(5), 660; https://doi.org/10.3390/pharmaceutics13050660
Received: 14 April 2021 / Revised: 29 April 2021 / Accepted: 1 May 2021 / Published: 5 May 2021
(This article belongs to the Special Issue Protein–Drug Interaction)
Flavonoids are among the most abundant natural bioactive compounds produced by plants. Many different activities have been reported for these secondary metabolites against numerous cells and systems. One of the most interesting is certainly the antimicrobial, which is stimulated through various molecular mechanisms. In fact, flavonoids are effective both in directly damaging the envelope of Gram-negative and Gram-positive bacteria but also by acting toward specific molecular targets essential for the survival of these microorganisms. The purpose of this paper is to present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins. Despite the great structural heterogeneity of these plant metabolites, it is interesting to observe that many flavonoids affect the same cellular pathways. Furthermore, it is evident that some of these compounds interact with more than one target, producing multiple effects. Taken together, the reported data demonstrate the great potential of flavonoids in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance. View Full-Text
Keywords: flavonoids; antibacterial activity; bioactive natural compounds; enzyme inhibitor; efflux pumps; ATP synthetase; DNA gyrase; antibiofilm activity flavonoids; antibacterial activity; bioactive natural compounds; enzyme inhibitor; efflux pumps; ATP synthetase; DNA gyrase; antibiofilm activity
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MDPI and ACS Style

Donadio, G.; Mensitieri, F.; Santoro, V.; Parisi, V.; Bellone, M.L.; De Tommasi, N.; Izzo, V.; Dal Piaz, F. Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids. Pharmaceutics 2021, 13, 660. https://doi.org/10.3390/pharmaceutics13050660

AMA Style

Donadio G, Mensitieri F, Santoro V, Parisi V, Bellone ML, De Tommasi N, Izzo V, Dal Piaz F. Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids. Pharmaceutics. 2021; 13(5):660. https://doi.org/10.3390/pharmaceutics13050660

Chicago/Turabian Style

Donadio, Giuliana, Francesca Mensitieri, Valentina Santoro, Valentina Parisi, Maria L. Bellone, Nunziatina De Tommasi, Viviana Izzo, and Fabrizio Dal Piaz. 2021. "Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids" Pharmaceutics 13, no. 5: 660. https://doi.org/10.3390/pharmaceutics13050660

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