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Article

Biodegradable Electrospun Nonwovens Releasing Propolis as a Promising Dressing Material for Burn Wound Treatment

1
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Skłodowskiej 34, 41-819 Zabrze, Poland
2
Department of Biopharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Poland
3
Department of Toxicology and Bioanalysis, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Ostrogórska 30, 41-200 Sosnowiec, Poland
4
Department of Community Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Kasztanowa 2, 41-205 Sosnowiec, Poland
5
Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Poland
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(9), 883; https://doi.org/10.3390/pharmaceutics12090883
Received: 3 July 2020 / Revised: 10 September 2020 / Accepted: 15 September 2020 / Published: 17 September 2020
(This article belongs to the Special Issue Design of Novel Polymeric Systems for Controlled Drug Delivery)
The selection of dressing is crucial for the wound healing process. Traditional dressings protect against contamination and mechanical damage of an injured tissue. Alternatives for standard dressings are regenerating systems containing a polymer with an incorporated active compound. The aim of this research was to obtain a biodegradable wound dressing releasing propolis in a controlled manner throughout the healing process. Dressings were obtained by electrospinning a poly(lactide-co-glycolide) copolymer (PLGA) and propolis solution. The experiment consisted of in vitro drug release studies and in vivo macroscopic treatment evaluation. In in vitro studies released active compounds, the morphology of nonwovens, chemical composition changes of polymeric material during degradation process, weight loss and water absorption were determined. For in vivo research, four domestic pigs, were used. The 21-day experiment consisted of observation of healing third-degree burn wounds supplied with PLGA 85/15 nonwovens without active compound, with 5 wt % and 10 wt % of propolis, and wounds rinsed with NaCl. The in vitro experiment showed that controlling the molar ratio of lactidyl to glycolidyl units in the PLGA copolymer gives the opportunity to change the release profile of propolis from the nonwoven. The in vivo research showed that PLGA nonwovens with propolis may be a promising dressing material in the treatment of severe burn wounds. View Full-Text
Keywords: electrospinning; drug delivery; PLGA; propolis; burn wounds electrospinning; drug delivery; PLGA; propolis; burn wounds
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MDPI and ACS Style

Stojko, M.; Włodarczyk, J.; Sobota, M.; Karpeta-Jarząbek, P.; Pastusiak, M.; Janeczek, H.; Dobrzyński, P.; Starczynowska, G.; Orchel, A.; Stojko, J.; Batoryna, O.; Olczyk, P.; Komosińska-Vassev, K.; Olczyk, K.; Kasperczyk, J. Biodegradable Electrospun Nonwovens Releasing Propolis as a Promising Dressing Material for Burn Wound Treatment. Pharmaceutics 2020, 12, 883. https://doi.org/10.3390/pharmaceutics12090883

AMA Style

Stojko M, Włodarczyk J, Sobota M, Karpeta-Jarząbek P, Pastusiak M, Janeczek H, Dobrzyński P, Starczynowska G, Orchel A, Stojko J, Batoryna O, Olczyk P, Komosińska-Vassev K, Olczyk K, Kasperczyk J. Biodegradable Electrospun Nonwovens Releasing Propolis as a Promising Dressing Material for Burn Wound Treatment. Pharmaceutics. 2020; 12(9):883. https://doi.org/10.3390/pharmaceutics12090883

Chicago/Turabian Style

Stojko, Mateusz; Włodarczyk, Jakub; Sobota, Michał; Karpeta-Jarząbek, Paulina; Pastusiak, Małgorzata; Janeczek, Henryk; Dobrzyński, Piotr; Starczynowska, Gabriela; Orchel, Arkadiusz; Stojko, Jerzy; Batoryna, Olgierd; Olczyk, Paweł; Komosińska-Vassev, Katarzyna; Olczyk, Krystyna; Kasperczyk, Janusz. 2020. "Biodegradable Electrospun Nonwovens Releasing Propolis as a Promising Dressing Material for Burn Wound Treatment" Pharmaceutics 12, no. 9: 883. https://doi.org/10.3390/pharmaceutics12090883

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