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Open AccessArticle

Ionically Crosslinked Complex Gels Loaded with Oleic Acid-Containing Vesicles for Transdermal Drug Delivery

by 1,2,3,*, 1 and 3
1
School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, China
2
School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China
3
Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(8), 725; https://doi.org/10.3390/pharmaceutics12080725
Received: 28 June 2020 / Revised: 21 July 2020 / Accepted: 27 July 2020 / Published: 2 August 2020
(This article belongs to the Special Issue Drug Delivery across Physiological Barriers)
Skin is an attractive site for drug administration partly because of its easy accessibility and favorable properties (e.g., less invasiveness and high patient compliance) over some other common routes of administration. Despite this, the efficiency in transdermal drug delivery has been largely limited by poor skin permeation. To address this problem, this study reports the generation of oleic acid-containing vesicles, which can enhance the drug delivery efficiency while showing good stability and limited skin disruption. Upon being loaded into a complex gel, along with the incorporation of the polymer blending technique, a delivery system exhibiting tunable transdermal flux of 2,3,5,4′-tetrahydroxystilbene 2-O-β-D-glucoside is reported. Taking the good biocompatibility and tunable delivery performance into account, our system warrants further development and optimization for future applications in the treatment of skin diseases. View Full-Text
Keywords: transdermal delivery; vesicles; gel; transdermal flux; skin permeation transdermal delivery; vesicles; gel; transdermal flux; skin permeation
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MDPI and ACS Style

Lai, W.-F.; Tang, R.; Wong, W.-T. Ionically Crosslinked Complex Gels Loaded with Oleic Acid-Containing Vesicles for Transdermal Drug Delivery. Pharmaceutics 2020, 12, 725.

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