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Open AccessArticle

Exploiting Lipid and Polymer Nanocarriers to Improve the Anticancer Sonodynamic Activity of Chlorophyll

1
Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy
2
Faculty of Pharmaceutical and Biochemical Sciences, Universidad Mayor de San Andrés, 3239 La Paz, Bolivia
3
National Institute of Metrological Research (INRIM), 10135 Torino, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to the work.
Pharmaceutics 2020, 12(7), 605; https://doi.org/10.3390/pharmaceutics12070605
Received: 30 May 2020 / Revised: 17 June 2020 / Accepted: 28 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Emergent Strategies for Natural Products Delivery)
Sonodynamic therapy is an emerging approach that uses low-intensity ultrasound to activate a sonosensitizer agent triggering its cytotoxicity for selective cancer cell killing. Several molecules have been proposed as sonosensitizer agents, but most of these, as chlorophyll, are strongly hydrophobic with a low selectivity towards cancer tissues. Nanocarriers can help to deliver more efficiently the sonosensitizer agents in the target tumor site, increasing at the same time their sonodynamic effect, since nanosystems act as cavitation nuclei. Herein, we propose the incorporation of unmodified plant-extracted chlorophyll into nanocarriers with different composition and structure (i.e., liposomes, solid lipid nanoparticles and poly(lactic-co-glycolic acid) nanoparticles) to obtain aqueous formulations of this natural pigment. The nanocarriers have been deeply characterized and then incubated with human prostatic cancer cells (PC-3) and spheroids (DU-145) to assess the influence of the different formulations on the chlorophyll sonodynamic effect. The highest sonodynamic cytotoxicity was obtained with chlorophyll loaded into poly(lactic-co-glycolic acid) nanoparticles, showing promising results for future clinical investigations on sonodynamic therapy. View Full-Text
Keywords: chlorophyll; liposomes; solid lipid nanoparticles; PLGA; ultrasound; sonodynamic treatment; sonosensitizer; cancer chlorophyll; liposomes; solid lipid nanoparticles; PLGA; ultrasound; sonodynamic treatment; sonosensitizer; cancer
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MDPI and ACS Style

Bosca, F.; Foglietta, F.; Gimenez, A.; Canaparo, R.; Durando, G.; Andreana, I.; Barge, A.; Peira, E.; Arpicco, S.; Serpe, L.; Stella, B. Exploiting Lipid and Polymer Nanocarriers to Improve the Anticancer Sonodynamic Activity of Chlorophyll. Pharmaceutics 2020, 12, 605. https://doi.org/10.3390/pharmaceutics12070605

AMA Style

Bosca F, Foglietta F, Gimenez A, Canaparo R, Durando G, Andreana I, Barge A, Peira E, Arpicco S, Serpe L, Stella B. Exploiting Lipid and Polymer Nanocarriers to Improve the Anticancer Sonodynamic Activity of Chlorophyll. Pharmaceutics. 2020; 12(7):605. https://doi.org/10.3390/pharmaceutics12070605

Chicago/Turabian Style

Bosca, Federica; Foglietta, Federica; Gimenez, Alberto; Canaparo, Roberto; Durando, Giovanni; Andreana, Ilaria; Barge, Alessandro; Peira, Elena; Arpicco, Silvia; Serpe, Loredana; Stella, Barbara. 2020. "Exploiting Lipid and Polymer Nanocarriers to Improve the Anticancer Sonodynamic Activity of Chlorophyll" Pharmaceutics 12, no. 7: 605. https://doi.org/10.3390/pharmaceutics12070605

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