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Open AccessReview

Protein-Based Nanoparticles as Drug Delivery Systems

by 1,†, 2,†, 3,†, 4,5,*, 6,* and 1,*
Department of Biotechnology and Bioengineering, Kangwon National University, Chuncheon 24341, Korea
Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea
Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon 16419, Korea
Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Korea
Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceutics 2020, 12(7), 604;
Received: 3 June 2020 / Revised: 26 June 2020 / Accepted: 26 June 2020 / Published: 29 June 2020
(This article belongs to the Special Issue Nanopharmaceuticals for Image-Guided Cancer Therapy and Diagnosis)
Nanoparticles have been extensively used as carriers for the delivery of chemicals and biomolecular drugs, such as anticancer drugs and therapeutic proteins. Natural biomolecules, such as proteins, are an attractive alternative to synthetic polymers commonly used in nanoparticle formulation because of their safety. In general, protein nanoparticles offer many advantages, such as biocompatibility and biodegradability. Moreover, the preparation of protein nanoparticles and the corresponding encapsulation process involved mild conditions without the use of toxic chemicals or organic solvents. Protein nanoparticles can be generated using proteins, such as fibroins, albumin, gelatin, gliadine, legumin, 30Kc19, lipoprotein, and ferritin proteins, and are prepared through emulsion, electrospray, and desolvation methods. This review introduces the proteins used and methods used in generating protein nanoparticles and compares the corresponding advantages and disadvantages of each. View Full-Text
Keywords: protein nanoparticle; drug delivery; biocompatible; biodegradable; controlled release protein nanoparticle; drug delivery; biocompatible; biodegradable; controlled release
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MDPI and ACS Style

Hong, S.; Choi, D.W.; Kim, H.N.; Park, C.G.; Lee, W.; Park, H.H. Protein-Based Nanoparticles as Drug Delivery Systems. Pharmaceutics 2020, 12, 604.

AMA Style

Hong S, Choi DW, Kim HN, Park CG, Lee W, Park HH. Protein-Based Nanoparticles as Drug Delivery Systems. Pharmaceutics. 2020; 12(7):604.

Chicago/Turabian Style

Hong, Seyoung; Choi, Dong W.; Kim, Hong N.; Park, Chun G.; Lee, Wonhwa; Park, Hee H. 2020. "Protein-Based Nanoparticles as Drug Delivery Systems" Pharmaceutics 12, no. 7: 604.

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