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Open AccessArticle

Topical Delivery of Meloxicam using Liposome and Microemulsion Formulation Approaches

1
Center for Dermal Research and Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ 08854, USA
2
Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(3), 282; https://doi.org/10.3390/pharmaceutics12030282
Received: 19 February 2020 / Revised: 11 March 2020 / Accepted: 19 March 2020 / Published: 21 March 2020
(This article belongs to the Special Issue Nanosystems as Drug Delivery Carrier: From Nature to the Medication)
The aim of this study is to develop, characterize and compare conventional liposome, deformable liposome (transfersome) and microemulsion formulations as potential topical delivery systems for meloxicam. Liposomes were characterized in terms of vesicle size, zeta potential and entrapment efficiency. For microemulsions, particle size, electrical conductivity and viscosity studies were performed to assess the structure of the investigated systems. An ex vivo skin permeation study has been conducted to compare these formulations. The dermal and transdermal delivery of meloxicam using these formulations can be a promising alternative to conventional oral delivery of non-steroidal anti-inflammatory drugs (NSAIDs) with enhanced local and systemic onset of action and reduced side effects. View Full-Text
Keywords: liposome; transfersome; microemulsion; meloxicam; ex vivo skin permeation liposome; transfersome; microemulsion; meloxicam; ex vivo skin permeation
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MDPI and ACS Style

Zhang, J.; Froelich, A.; Michniak-Kohn, B. Topical Delivery of Meloxicam using Liposome and Microemulsion Formulation Approaches. Pharmaceutics 2020, 12, 282.

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